PMID: 6412264Jan 1, 1983Paper

Ethanol effects on brain concentrations of amitriptyline and the relationship to psychomotor function

Psychopharmacology
S H Preskorn, C W Hughes

Abstract

The effect of amitriptyline (AMI), ethanol (ETOH), and ETOH followed by AMI on both general activity (open field) and motor performance (two rotorod tasks) was tested in reference to a saline-injected control. The combination (ETOH plus AMI) produced greater impairment on all three tasks than did either drug alone. ETOH pretreatment also produced a 223% increase in the total tricyclic antidepressant (TCA) brain concentration. The decrement in motor performance was logarithmically related to total TCA brain concentrations in both animals treated with AMI alone and those pretreated with ETOH prior to AMI. The concentration which consistently produced behavioral impairment was similar to those previously reported to cause cognitive and electroencephalographic dysfunction in humans.

References

Apr 1, 1978·Physiology & Behavior·C W Hughes
Oct 1, 1984·Journal of Clinical Psychopharmacology·S H PreskornE Othmer
Jan 1, 1982·Psychopharmacology·S H Preskorn, R K Glotzbach
Jun 1, 1982·The American Journal of Psychiatry·S H Preskorn, S Simpson

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Citations

Jun 30, 2005·Journal of Psychiatric Practice·Sheldon H Preskorn
Jan 1, 1987·International Journal of Psychiatry in Medicine·S H Preskorn, D W Goodwin

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