Ethanol effects on lipid peroxidation and glutathione-mediated defense in rat small intestine: role of dietary fats

Alcohol
M KaurAkhtar Mahmood

Abstract

The effect of ethanol feeding for 5 weeks on lipid peroxidation status of small intestine was studied in rats maintained on either a rat pellet (RP) or a semisynthetic diet containing coconut oil (CCO), corn oil (CO), or fish oil (FO). Highest rate of iron/ascorbate-induced lipid peroxidation was observed in intestinal mucosa of FO-fed rats, which was further elevated (p < 0.05) upon ethanol administration. Purified brush borders from all the ethanol-treated dietary groups were more susceptible to iron-induced lipid peroxidation. Level of nonprotein thiols was increased by ethanol feeding to rats given CO or FO. FO-fed rats exhibited increased activities of glutathione reductase (GR), glutathione-S-transferase (GST), and catalase (Cat). Glutathione peroxidase (GPx) was the lowest in the CCO group. Ethanol-treated FO group exhibited increased GST and GPx activities compared to controls, whereas in rats fed the RP or CO diet, ethanol feeding significantly decreased GST activity. GR and Cat activities were not affected under these conditions. Thus, ethanol exposes the small intestinal mucosa to oxidative stress. The effects were more pronounced in rats fed n-3 fatty acid-rich (FO) diet. The corresponding rise in GPx and GST levels...Continue Reading

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Citations

Apr 8, 2010·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Amandeep Kaur KalraAkhtar Mahmood
Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Pintu D Masalkar, Subodhini A Abhang
Jul 15, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·Junqiang TianThomas R Ziegler
Dec 3, 2014·Alcohol·P Hari PriyaP Sreenivasula Reddy
Sep 10, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·J X RongA Sevanian
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wei ZhongZhanxiang Zhou
Jan 8, 2004·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Heather JefferiesRosalie D McCauley

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