PMID: 8602119Jan 1, 1996Paper

Ethanol enhances the in situ phosphorylation of MARCKS and protein kinase C activity in primary cultures of astrocytes

Life Sciences
T L Smith, M S Bitrick

Abstract

Protein kinase C (PKC) plays an important regulatory role in astrocyte function. Chronic exposure to ethanol for 4 days resulted in an increase in Ca2+-dependent PKC activity in the supernatant fraction of astrocyte homogenates. Only Ca2+-independent PKC activity could be observed in the membrane fraction and this activity was unaffected by ethanol exposure. Chronic ethanol exposure also increased the in situ phosphorylation of MARCKS in permeabilized astrocytes both in the absence or presence of the PKC activator, phorbol 12 -myristate 13 -acetate (PMA). These results suggest an increase in the expression of one or more astrocytic PKC isoforms after chronic ethanol exposure.

References

Jan 1, 1991·Pharmacology & Therapeutics·S Stabel, P J Parker
Mar 1, 1991·Neuron·M V BennettJ C Sáez
Jan 1, 1990·Life Sciences·S Skwish, W Shain
Feb 18, 1986·European Journal of Pharmacology·B PearceS Murphy
Feb 1, 1994·Alcoholism, Clinical and Experimental Research·L D SnellP L Hoffman
May 15, 1994·The Biochemical Journal·R D Raffaniello, J P Raufman
Oct 1, 1993·Alcoholism, Clinical and Experimental Research·T L Fletcher, W Shain
Apr 15, 1993·The Biochemical Journal·H Hug, T F Sarre
Apr 1, 1993·Alcoholism, Clinical and Experimental Research·P B DePetrillo, C S Liou

❮ Previous
Next ❯

Citations

Sep 19, 1998·Free Radical Biology & Medicine·C DomenicottiM A Pronzato
Sep 9, 2006·Journal of Gastroenterology and Hepatology·Dongmei WuXianglin Shi
Oct 8, 1999·Alcoholism, Clinical and Experimental Research·C D Stubbs, S J Slater
May 23, 1998·Annual Review of Pharmacology and Toxicology·L G Costa
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Eric N ChurchillDaria Mochly-Rosen
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Moe Moe AyeJia Luo
Nov 20, 1997·The Journal of Urology·P A WhitsonC Y Pak
Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·M Cristina ErricoAlessandra Carè
Sep 25, 1999·Clinics in Dermatology·R WolfV Ruocco
Jun 3, 2021·International Journal of Molecular Sciences·Zita Szentkereszty-KovácsDániel Törőcsik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.