Ethanol extract and its dichloromethane fraction of Alpinia oxyphylla Miquel exhibited hepatoprotective effects against CCl4 -induced oxidative damage in vitro and in vivo with the involvement of Nrf2

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Qiao ZhangQingchun Zhao

Abstract

Alpinia oxyphylla Miq. (A. oxyphylla), as a kind of medicine which also be used as food, is widely used in East Asian for the treatment of dyspepsia, diarrhea, abdominal pain and deficiency cold of spleen and stomach. This study aimed to investigate the protective effects of ethanol extract (EE) and its dichloromethane fraction (DM) of A. oxyphylla, which are rich in phenolic compounds, against CCl4-induced hepatic injury in vitro and in vivo. EE, DM and silymarin ameliorated CCl4-induced decrease of cell viability and increase of reactive oxygen species (ROS) in HepG2 cells. The CCl4-induced changes of glutathione (GSH) and methane dicarboxylic aldehyde (MDA) levels, and the decrease of superoxide dismutase (SOD) and catalase (CAT) activities were all restored with the pretreatment of EE, DM and silymarin. The results in liver injury model in rats showed that EE, DM and silymarin could significant decrease the levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin than the model group. Liver histopathology revealed that EE and DM attenuated the incidence of liver lesions triggered by CCl4intoxication. They also effectively relieved CCl4-induced oxidative...Continue Reading

Citations

May 1, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Burcu Gul BaykalirHuseyin Fatih Gul
Sep 21, 2017·Experimental and Therapeutic Medicine·Yujuan ChangXiaolan Su
Apr 20, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Kuo-Kuei HuangJia-Ling Yang
Jul 8, 2019·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Le Van Manh HungSomi Kim Cho
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jia LiZhi Sun
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fuhai HuiQingchun Zhao

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