Abstract
Brassica rapa L. ssp. pekinensis, commonly known as Chinese cabbage, is a cruciferous vegetable traditionally consumed in east Asia. Although its habitual consumption could account for the low incidence of chronic vascular inflammation, the therapeutic and protective potential of phytochemicals derived from Chinese cabbage has been poorly studied. In this study, we identified the phenolic compounds, kaempferol and quercetin, from the ethanol extract of Chinese cabbage (EtCC). We show for the first time that EtCC contains effective phytochemicals that suppress tumor necrosis factor (TNF)-α-induced inflammatory response in human umbilical vein endothelial cells. The EtCC inhibited TNF-α-induced monocyte adhesion to endothelial cells in a dose-dependent manner. The antiadhesive activity of EtCC directly correlated with downregulation of expression and transcription of vascular cell adhesion molecule-1 (VCAM-1). It was caused by an Nrf-2-dependent mechanism, leading to activation of antioxidant responsive element-driven promoter. Taken together, these results suggest that EtCC inhibits the expression of TNF-α-induced adhesion molecules through the indirect transcriptional modulation of VCAM-1 in endothelial cells. In conclusion, re...Continue Reading
References
May 8, 2001·Immunologic Research·D A Steeber, T F Tedder
Oct 14, 2003·Public Health Nutrition·Soo-Kyung Lee, Jeffery Sobal
Apr 1, 2004·Die Nahrung·Ilona SchonhofBernhard Brückner
Apr 29, 2004·The Journal of Nutrition·Jung-Suk ChoiYoung-Hee Kang
Dec 1, 2004·The Journal of Nutrition·Gail K McWalterJohn D Hayes
Mar 9, 2005·Cancer Research·Sunga Choi, Shivendra V Singh
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dong XiaoShivendra V Singh
Dec 27, 2005·Journal of Chromatography. a·Y-S LiangR Verpoorte
Feb 16, 2006·Journal of Agricultural and Food Chemistry·Annalisa RomaniDaniela Heimler
Jun 22, 2006·Journal of Agricultural and Food Chemistry·Simone J RochfortBruce Tomkins
May 15, 2007·Platelets·Mirella NardiniCristina Scaccini
Aug 2, 2007·Journal of Cardiovascular Pharmacology·Yong Sook KimJung Chaee Kang
Aug 7, 2007·The Journal of Biological Chemistry·Jianguo WangArne Slungaard
Jun 3, 2008·Cellular and Molecular Life Sciences : CMLS·A SalminenJ Huuskonen
Jul 22, 2008·The Journal of Nutrition·Davide GrassiGiovambattista Desideri
Apr 10, 2009·Current Pharmaceutical Design·Davide GrassiClaudio Ferri
Apr 22, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ana García-LafuenteJosé Alfredo Martínez
May 7, 2009·Acta Pharmacologica Sinica·Xiang WuKe Xu
Sep 5, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Mustafa ZakkarPaul C Evans
Oct 30, 2009·Autoimmunity·Georgios Foteinos, Qingbo Xu
Apr 27, 2010·Brain Research·Zhang PingXuejun Sun
Jun 29, 2010·The Journal of Nutritional Biochemistry·Christine Boesch-SaadatmandiGerald Rimbach
Apr 21, 2011·Diabetes Care·Soo LimKwang Kon Koh
May 20, 2011·The American Journal of Clinical Nutrition·Xianglan ZhangWei Zheng
Jan 29, 2014·Preventive Nutrition and Food Science·Eunyoung Hong, Gun-Hee Kim
May 4, 2017·Integrative Medicine Research·Ki Mo LeeByeong Hwa Jeon