Ethanol Extract of Lilium Bulbs Plays an Anti-Inflammatory Role by Targeting the IKK[Formula: see text]/[Formula: see text]-Mediated NF-[Formula: see text]B Pathway in Macrophages

The American Journal of Chinese Medicine
Sang Yun HanJae Youl Cho

Abstract

Lilium bulbs have long been used as Chinese traditional medicines to alleviate the symptoms of various human inflammatory diseases. However, mechanisms of Lilium bulb-mediated anti-inflammatory activity and the bioactive components in Lilium bulbs remain unknown. In the present study, the anti-inflammatory activity of Lilium bulbs and the underlying mechanism of action were investigated in macrophages using Lilium bulb ethanol extracts (Lb-EE). In a dose-dependent manner, Lb-EE inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and bone marrow-derived macrophages (BMDMs) without causing significant cytotoxicity. Lb-EE also down-regulated mRNA expression of inflammatory genes in LPS-stimulated RAW264.7 cells, which included inducuble nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), and tumor necrosis factor-[Formula: see text] (TNF-[Formula: see text]). Furthermore, Lb-EE markedly restored LPS-induced morphological changes in RAW264.7 cells to a normal morphology. HPLC analysis identified quercetin, luteolin, and kaempferol as bioactive components contained in Lb-EE. Mechanistic studies in LPS-stimulated RAW264.7 cells revealed that Lb-EE suppressed MyD88- and TRIF-induced NF-[Form...Continue Reading

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Citations

Mar 13, 2020·The American Journal of Chinese Medicine·Minkyeong JoJae Youl Cho
Mar 29, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kun Kuk ShinJae Youl Cho
Jan 2, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Stephanie Triseptya HuntoJae Youl Cho
Jan 12, 2021·Complementary Therapies in Clinical Practice·Saeed Ebrahimi FanaMahmood Maniati
Mar 30, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·So-Hyeon HwangJae Youl Cho

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