Ethanol extracts collected from the Styela clava tunic alleviate hepatic injury induced by carbon tetrachloride (CCl4) through inhibition of hepatic apoptosis, inflammation, and fibrosis

Journal of Toxicologic Pathology
Eun Kyoung KohDae Youn Hwang

Abstract

The Styela clava tunic (SCT) is known as a good raw material for preparing anti-inflammatory compounds, wound healing films, guided bone regeneration, and food additives. To investigate whether ethanol extracts of the SCT (EtSCT) could protect against hepatic injury induced by carbon tetrachloride (CCl4) in ICR mice, alterations in serum biochemical indicators, histopathology, hepatic apoptosis, inflammation, and fibrosis were observed in ICR mice pretreated with EtSCT for 5 days before CCl4 injection. EtSCT contained 15.6 mg/g of flavonoid and 37.5 mg/g phenolic contents with high 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity (93.3%) and metal chelation activity (46.5%). The EtSCT+CCl4-treated groups showed decreased levels of ALT, LDH, and AST, indicating toxicity and a necrotic area in the liver, while the level of ALP remained constant. The formation of active caspase-3 and enhancement of Bax/Bcl-2 expression was effectively inhibited in the EtSCT+CCl4-treated groups. Furthermore, the levels of pro- and anti-inflammatory cytokines and the phosphorylation of p38 in the TNF-α downstream signaling pathway rapidly recovered in the EtSCT+CCl4-treated groups. The EtSCT+CCl4-treated groups showed a significant d...Continue Reading

References

Jun 15, 1994·Biochemical and Biophysical Research Communications·L MarcocciL Packer
Sep 16, 2000·Biochemical Society Symposium·G C Brown, V Borutaite
Nov 28, 2000·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L FriedmanD M Bissell
Apr 27, 2001·Toxicology Letters·M I LusterB Yucesoy
Jul 28, 2001·European Journal of Gastroenterology & Hepatology·G Ramadori, T Armbrust
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dae Y HwangYong K Kim
Apr 24, 2003·Critical Reviews in Toxicology·Lutz W D WeberAndreas Stampfl
May 2, 2003·Phytotherapy Research : PTR·Hyuncheol OhYoun-Chul Kim
Oct 28, 2004·Gastroenterology·Giovanna FattovichFrancesco Donato
Mar 11, 2005·Journal of Clinical Gastroenterology·Rebecca G Wells
Apr 28, 2006·The Journal of Pharmacy and Pharmacology·Tzung-Yan LeeHan-Chieh Lin
Jul 14, 2007·Journal of Dermatological Science·Hironobu Ihn
Jul 19, 2008·World Journal of Gastroenterology : WJG·Yukihiro Shimizu
Sep 2, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yu-Wen HsuFung-Jou Lu
Sep 24, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hye-Jeong HwangTaek-Jeong Nam
Mar 3, 2009·Annals of the New York Academy of Sciences·C BerasainM A Avila
Aug 10, 2010·Parasitology Research·Hílton Antonio Mata-SantosAlexandre dos Santos Pyrrho
Nov 16, 2010·Annual Review of Pathology·Virginia Hernandez-Gea, Scott L Friedman
Jun 28, 2011·BMC Complementary and Alternative Medicine·Sumaira SahreenRahmat A Khan
Jul 12, 2011·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Li LiYong Woo Lee
Sep 1, 2008·Environmental Toxicology and Pharmacology·Nandita SinghP S Rajini
Dec 7, 2011·Biochemia Medica·Mehmet KoseogluSerap Cuhadar
Apr 21, 2012·Environmental Toxicology and Pharmacology·Binan LuJinyong Peng
May 1, 2012·Clinics in Liver Disease·Asma Siddique, Kris V Kowdley
Jan 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shuai ZhangJinyong Peng
Jul 11, 2013·World Journal of Gastroenterology : WJG·Xiao-Ling GuoQin Cao
Mar 1, 2014·Journal of Materials Science. Materials in Medicine·Sung Hwa SongDae Youn Hwang
Apr 15, 2014·Environmental Toxicology and Pharmacology·Jie-Qiong MaChan-Min Liu
Oct 26, 2014·BMC Complementary and Alternative Medicine·Ya-Ling HouJane C-J Chao
Oct 17, 2015·Laboratory animal research·Eun-Kyoung KohDae-Youn Hwang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
chemical treatment
light microscopy
MDA
electrophoresis
Assay
ELISA

Software Mentioned

SPSS
Leica Application Suite
SPSS Statistics

Related Concepts

Related Feeds

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here