Ethanol facilitates socially evoked memory recall in mice by recruiting pain-sensitive anterior cingulate cortical neurons

Nature Communications
Tetsuya SakaguchiYuji Ikegaya

Abstract

Alcohol is a traditional social-bonding reinforcer; however, the neural mechanism underlying ethanol-driven social behaviors remains elusive. Here, we report that ethanol facilitates observational fear response. Observer mice exhibited stronger defensive immobility while observing cagemates that received repetitive foot shocks if the observer mice had experienced a brief priming foot shock. This enhancement was associated with an observation-induced recruitment of subsets of anterior cingulate cortex (ACC) neurons in the observer mouse that were responsive to its own pain. The vicariously activated ACC neurons projected their axons preferentially to the basolateral amygdala. Ethanol shifted the ACC neuronal balance toward inhibition, facilitated the preferential ACC neuronal recruitment during observation, and enhanced observational fear response, independent of an oxytocin signaling pathway. Furthermore, ethanol enhanced socially evoked fear response in autism model mice.

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Citations

Dec 17, 2019·Alcoholism, Clinical and Experimental Research·Scott EdwardsKatie Witkiewitz
Apr 6, 2020·Social Cognitive and Affective Neuroscience·Isabella C WagnerClaus Lamm
Sep 17, 2020·Cerebral Cortex·Satoshi Iwasaki, Yuji Ikegaya
Apr 10, 2019·Molecular Brain·Xin-Shang WangShui-Bing Liu
Nov 28, 2019·Molecular Neurobiology·C GrasselliL De Filippis
Dec 6, 2019·PLoS Biology·Yingying HanChristian Keysers
Mar 30, 2020·Scientific Reports·Tuce TombazJonathan R Whitlock
Mar 24, 2021·Current Opinion in Neurobiology·Enrica ParadisoChristian Keysers
Jun 9, 2021·Current Biology : CB·Christian Keysers, Valeria Gazzola
Jun 7, 2021·Current Opinion in Neurobiology·Seong-Wook KimHee-Sup Shin
Jun 9, 2021·Neuroscience and Biobehavioral Reviews·Andrey E Ryabinin, Hannah D Fulenwider
Jul 14, 2021·ELife·Inbal Ben-Ami BartalDaniela Kaufer
Oct 7, 2020·Neuroscience and Biobehavioral Reviews·Julen Hernandez-LallementMaria Carrillo

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Methods Mentioned

BETA
catFISH
sedation

Software Mentioned

Arc catFISH
MATLAB

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