Ethanol increases GABA release in the embryonic avian retina

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Fernanda Pohl-GuimarãesRicardo Augusto de Melo Reis

Abstract

Several mechanisms underlying ethanol action in GABAergic synapses have been proposed, one of these mechanisms is on GABA release. Here, we report that in ovo exposure to ethanol induces an increase on GABA release in the embryonic chick retina. Eleven-day-old chick embryos (E11) received an injection of either phosphate buffer saline (PBS) or ethanol (10%, v/v, diluted in PBS), and were allowed to develop until E16. A single glutamate stimulus (2 mM) showed approximately a 40% increase on GABA release in E16 retinas when compared to controls. The effect was dependent on NMDA receptors and GAD65 mRNA levels, which were increased following the ethanol treatment. However, the numbers of GABA-, GAD-, and NR1-immunoreactive cells, and the expression levels of these proteins, were not affected. We conclude that ethanol treatment at a time point when synapses are being formed during development selectively increases GABA release in the retina via a NMDA receptor-dependent process.

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Citations

Feb 24, 2015·Neurochemistry International·Clarissa S SchitineRicardo A M Reis
May 26, 2016·Journal of Neurochemistry·Rafael BritoKarin C Calaza
Oct 13, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·George R Flentke, Susan M Smith
Mar 7, 2019·Molecular Neurobiology·Hércules Rezende FreitasGuilherme Rapozeiro França
Sep 30, 2019·Neurochemistry International·Vladimir Pedro Peralva Borges-MartinsRegina Célia Cussa Kubrusly

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