Ethanol-induced anxiolysis and neuronal activation in the amygdala and bed nucleus of the stria terminalis

Alcohol
Amanda C SharkoMarlene A Wilson

Abstract

High rates of comorbidity for anxiety and alcohol-use disorders suggest a causal relationship between these conditions. Previous work demonstrates basal anxiety levels in outbred Long-Evans rats correlate with differences in voluntary ethanol consumption and that amygdalar Neuropeptide Y (NPY) systems may play a role in this relationship. The present work explores the possibility that differences in sensitivity to ethanol's anxiolytic effects contribute to differential ethanol self-administration in these animals and examines the potential role of central and peripheral NPY in mediating this relationship. Animals were first exposed to the elevated plus maze (EPM) to assess individual differences in anxiety-like behaviors and levels of circulating NPY and corticosterone (CORT). Rats were then tested for anxiety-like behavior in the light-dark box (LD box) following acute ethanol treatment (1 g/kg; intraperitoneally [i.p.]), and neuronal activation in the amygdala and bed nucleus of the stria terminalis (BNST) was assessed using Fos immunohistochemistry. EPM exposure increased plasma CORT levels without altering plasma NPY levels. Acute ethanol treatment significantly increased light-dark transitions and latency to re-enter the l...Continue Reading

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Feb 1, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Juan Antonio García-CarmonaMaria Luisa Laorden
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May 1, 2021·International Journal of Molecular Sciences·Johannes Kornhuber, Iulia Zoicas

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