Ethanol-induced c-Fos expression in rat lines selected for low and high alcohol consumption

Brain Research
Todd E ThieleI L Bernstein

Abstract

Selectively bred rat lines, developed to model genetic contributions to alcohol abuse, include the Indiana alcohol-preferring (P) and alcohol-nonpreferring (NP) lines, and the Alko-Alcohol (AA) and Alko-Nonalcohol (ANA) lines. Preferring and nonpreferring lines were compared in their response to intraperitoneal injection of either ethanol or isotonic saline using c-Fos expression as a marker of neuronal activity. Although line differences were noted in several brain regions, the principal finding was that alcohol-nonpreferring lines (NP and ANA) displayed greater c-Fos expression in the locus coeruleus (LC) relative to the alcohol-preferring lines (P and AA) following injection of 3.0 g ethanol/kg. These data point to the LC as an area which may play a role in the differences in voluntary ethanol consumption between rat lines genetically bred for low and high ethanol preference.

References

Nov 4, 1988·Science·G F Koob, F E Bloom
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Sep 1, 1996·Alcoholism, Clinical and Experimental Research·T E ThieleI L Bernstein

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Citations

Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·William J McBride
Aug 26, 1998·Drug and Alcohol Dependence·J C Crabbe, T J Phillips
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Apr 23, 2008·Neurochemical Research·Jeanette LindholmBjörn Johansson
Oct 6, 2020·Addiction Biology·Patrick A RandallJoyce Besheer

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