Ethanol-induced conditioned taste aversion to ethanol

Alcohol
J D Sinclair

Abstract

A single injection of 2.5 g/kg ethanol one hr after drinking a 10% ethanol-0.05% saccharin solution produced a persistent conditioned taste aversion to the ethanol-saccharin solution. Twelve pairings produced a still stronger aversion that generalized to an aversion to a 10% ethanol solution without saccharin. Unpaired presentations of ethanol-saccharin solution and ethanol injections prevented the subsequent development of an aversion from a single pairing. Twelve pairings of access to saccharin solution with ethanol injections produced an aversion that generalized to an ethanol-saccharin solution. All groups receiving 12 alternate-day ethanol injections developed tolerance to the hypothermic effect of ethanol, but the tolerance was not conditioned to the drinking fluids previously paired with ethanol injections and it was unrelated to the subsequent drinking behaviors.

References

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Citations

Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·D S Cannon, L E Carrell
Jul 1, 1987·Pharmacology, Biochemistry, and Behavior·H H SamsonF G Mills
Mar 27, 2001·Pharmacology, Biochemistry, and Behavior·K Ackroff, A Sclafani
Oct 12, 2002·Pharmacology, Biochemistry, and Behavior·Karen Ackroff, Anthony Sclafani
May 22, 2003·Pharmacology, Biochemistry, and Behavior·Karen Ackroff, Anthony Sclafani
Aug 1, 1995·Alcoholism, Clinical and Experimental Research·P J KulkoskyL M Hopkins
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·R ArnonM A Zern
Aug 1, 1993·Psychological Reports·F A Logan

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