Ethanol-induced depletion of lymphocytes from the mesenteric lymph nodes of C57B1/6 mice is associated with RNA but not DNA degradation

Alcoholism, Clinical and Experimental Research
D A SibleyT R Jerrells

Abstract

The effects of ethanol (EtOH) consumption by adult female C57B1/6 mice on lymphocyte populations of the mesenteric lymph nodes (MLNs) were determined by feeding mice with the Lieber-DeCarli liquid diet by a pair-feeding paradigm. Histological analysis of the MLNs of EtOH-fed mice showed a progressive loss of lymphocytes from the medullary regions at 3, 5, and 7 days after initiation of the EtOH diet. The stromal cells in the medullary region also demonstrated a progressive alteration in stellate morphological features at times corresponding to those of loss of lymphocytes from this region. Microscopic evaluation of the follicle regions of MLNs obtained from mice fed an EtOH-containing diet showed no appreciable alterations in morphological characteristics. The number of tingible body macrophages in the germinal centers of the follicles, however, was increased after 3 days of EtOH diet feeding and declined progressively after this time. Flow cytometric analysis of isolated lymphocytes showed a depletion of both T and B cell populations from the MLNs. In contrast to B cells, however, T cells were depleted through 7 days of EtOH diet feeding. Total RNA isolated from the MLNs of mice consuming the EtOH-containing diet was progressi...Continue Reading

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Citations

Nov 26, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Hao WangMichael Wolcott
Sep 4, 1998·Alcoholism, Clinical and Experimental Research·J E Shellito
Sep 4, 1998·Alcoholism, Clinical and Experimental Research·T R JerrellsK A Mitchell
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May 28, 2020·Experimental & Molecular Medicine·Young-Ri Shim, Won-Il Jeong

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