Abstract
The susceptibility to ethanol-induced lesions was studied in rats with experimental hypertrophic gastropathy, in order to examine the nature of gastric mucosal resistance in this condition. Acute erosions were induced by a standard per os method of administration with graded concentrations of ethanol; underlying mucosal hypertrophic gastropathy was induced by infection with Taenia taeniaeformis. The gastric mucosal content of histamine and serotonin was also assessed. Hypertrophic gastropathy was characterized by mucus cell hyperplasia, greatly increased stomach weight, increased mucosal content of histamine, and no effect in resistance to gastric injury induced by graded doses of ethanol. Correlated changes in serotonin content with treatment were not observed, but mucosal histamine content was correlated inversely with ethanol administration in both parasite-infected and non-infected rats. This model of hypertrophic gastropathy could be of interest to study the pathogenesis of hypertrophic gastropathy and its response to known injurious agents.
References
Dec 1, 1977·The American Journal of Digestive Diseases·R J Biggerstaff, G J Leitch
May 1, 1978·Analytical Biochemistry·S T Ohnishi, J K Barr
Jan 1, 1979·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J L BalibreaL Avila
Mar 1, 1978·European Journal of Pharmacology·C H Cho, C W Ogle
Jan 1, 1988·Gastroenterology·P J Oates, J P Hakkinen
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·C H ChoC W Ogle
Apr 1, 1973·Parasitology·L M McLEAYD A Titchen
Jun 1, 1972·Analytical Biochemistry·R HåkansonK Sjölund
Mar 1, 1967·Toxicology and Applied Pharmacology·C J Pfeiffer, P J Muller
Feb 15, 1982·Experientia·S Szabo, K H Usadel
Sep 1, 1983·Veterinary Parasitology·J R Brandt, M M Sewell
Jan 1, 1984·Digestion·C H ChoC J Pfeiffer
Jun 1, 1982·Parasitology·C H Cho, D F Mettrick
Oct 9, 1981·Science·S SzaboP W Frankel
Jul 1, 1980·IEEE Transactions on Bio-medical Engineering·N Hogan, R W Mann
Jun 24, 1961·Lancet·P A BALL, A H JAMES
May 8, 1965·Lancet·D J DUPLESSIS