PMID: 7059417Feb 1, 1982

Ethanol-induced increase in procainamide acetylation in man

British Journal of Clinical Pharmacology
H Olsen, J Mørland

Abstract

1 The effect of ethanol on procainamide pharmacokinetics was studied in humans by two different experimental designs. In one, ethanol was given 1.5 h after taking the drug followed by hourly drinks, while in the other ethanol was given 2 h before and subsequently after taking the drug. 2 In both studies, ethanol caused a significant reduction of T1/2 and a significant increase in total clearance of procainamide, while the apparent volume of distribution of procainamide, as well as the renal clearance of both procainamide and N-acetylprocainamide were unaffected by ethanol treatment. 3 Ethanol treatment increased the percentage of N-acetylprocainamide measured in blood and urine and the ratio of AUCNAPA/AUCPA significantly. 4 The T1/2 and total clearance of procainamide was significantly different in slow and rapid acetylators.

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Citations

Jan 1, 1996·Journal of Clinical Pharmacology·J E TisdaleB J Zarowitz
Jan 1, 1983·European Journal of Clinical Pharmacology·H OlsenP K Lunde
Nov 30, 2004·European Journal of Clinical Pharmacology·R G DattaniP A Routledge
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·H Olsen, J Mørland
Jan 1, 1989·Pharmacology & Therapeutics·D S Sitar
Jan 1, 1989·Pharmacology & Therapeutics·D A Evans
Jun 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·H ZaherC K Svensson
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Jul 1, 1988·British Journal of Clinical Pharmacology·M D LittleyJ H Lazarus
Oct 1, 1993·Acta Ophthalmologica·E G Olsen, H Olsen

Related Concepts

Acetic Acids
Acetylation
Ethanol
Drug Interactions
Half-Life
Rhythmin

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