PMID: 3758935Sep 1, 1986Paper

Ethanol-induced liver fibrosis in rats fed high fat diet

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
H TsukamotoS W French

Abstract

Severe hepatic steatosis and focal necrosis of hepatocytes have previously been induced in rats by continuous intragastric infusion of ethanol and a diet containing only 5% fat as a per cent of total calories as reported by us previously. Since the ethanol diet fed ad libitum with such a low level of fat has previously failed to produce alcoholic fatty liver, continuously high blood alcohol levels achieved in this model appeared to be key in induction of the progressive pathologic lesions in the liver. In the current study, effects of increased fat intake on alcohol-induced liver injury were investigated. Seventeen pairs of male Wistar rats were implanted with gastrostomy cannulas and infused with a liquid diet containing 25% of total calories as fat plus ethanol or isocaloric dextrose. Ethanol intake was progressively increased from 32% up to 47% of total calories to maintain sustained intoxication for 30 to 120 days. Light and electron microscopic examination of the liver revealed moderate to severe fatty infiltration in all of the ethanol-fed rats, of which 14 had spotty or zonal necrosis in the centrilobular areas accompanied by polymorphonuclear and mononuclear cell infiltration. In addition, fibrosis was observed in assoc...Continue Reading

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Citations

May 1, 1996·The Anatomical Record·B TandlerH Tsukamoto
Oct 2, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E Mezey
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