Ethanol inhibits neuritogenesis induced by astrocyte muscarinic receptors.

Glia
Marina GuizzettiLucio G Costa

Abstract

In utero alcohol exposure can lead to fetal alcohol spectrum disorders, characterized by cognitive and behavioral deficits. In vivo and in vitro studies have shown that ethanol alters neuronal development. We have recently shown that stimulation of M(3) muscarinic receptors in astrocytes increases the synthesis and release of fibronectin, laminin, and plasminogen activator inhibitor-1, causing neurite outgrowth in hippocampal neurons. As M(3) muscarinic receptor signaling in astroglial cells is strongly inhibited by ethanol, we hypothesized that ethanol may also inhibit neuritogenesis in hippocampal neurons induced by carbachol-stimulated astrocytes. In the present study, we report that the effect of carbachol-stimulated astrocytes on hippocampal neuron neurite outgrowth was inhibited in a concentration-dependent manner (25-100 mM) by ethanol. This effect was because of the inhibition of the release of fibronectin, laminin, and plasminogen activator inhibitor-1. Similar effects on neuritogenesis and on the release of astrocyte extracellular proteins were observed after the incubation of astrocytes with carbachol in the presence of 1-butanol, another short-chain alcohol, which like ethanol is a competitive substrate for phosphol...Continue Reading

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Citations

Dec 5, 2013·Neuroscience and Biobehavioral Reviews·Fares Zeidán-ChuliáJosé Cláudio Fonseca Moreira
Jan 23, 2016·Frontiers in Integrative Neuroscience·Clare J Wilhelm, Marina Guizzetti
Nov 27, 2014·Frontiers in Pediatrics·Marina GuizzettiDavid P Gavin
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Jan 24, 2016·Journal of Neurochemistry·Pablo TrindadeAlexandre E Medina
Sep 15, 2018·Frontiers in Genetics·David P GavinMarina Guizzetti

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