Ethanol intake after chronic intoxication by inhalation of ethanol vapour in rats: behavioural dependence

Alcohol
G AufrèreF Beaugé

Abstract

In Wistar rats, which practically avoid ethanol when naive, it is possible to induce a large ethanol intake in a free-choice situation after chronic intoxication by ethanol vapour. In this study, we evaluated the ethanol intake of chronically intoxicated and control rats. The ethanol intake was increased in intoxicated animals but the intensity of the response varied according to individuals without any clear relation to the level of the intoxication. The results clearly showed in intoxicated animals two kinds of responders: alcohol-nonpreferring (27/95) and alcohol-preferring rats (68/95). In the alcohol-preferring rats, ethanol intoxication had induced an alcohol drinking-dependent behaviour; about 75% of the animals of this group drank more than 7 g/kg b.wt. per day and could be considered as behaviourally dependent on alcohol. Furthermore, this group presents most of the criteria of alcoholism that an animal model should ideally satisfy.

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Citations

Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·M NaassilaM Daoust
Feb 13, 2003·Neuroscience Letters·Mickaël NaassilaMartine Daoust
Jul 20, 2002·Drug and Alcohol Dependence·U W PreussG P Danko
Jan 20, 2007·Genes, Brain, and Behavior·J S RhodesJ C Crabbe
Dec 25, 2010·Indian Journal of Psychiatry·Pradeep R JohnsonM V Ashok
Oct 31, 2015·Pharmacology, Biochemistry, and Behavior·Melissa MoralesBrian A McCool
Mar 28, 2007·Alcoholism, Clinical and Experimental Research·Eric M TruxellNorman E Spear
Sep 15, 2016·Alcohol·Nicholas J JuryAndrew Holmes
Nov 16, 2004·European Journal of Pharmacology·Elena Terenina-RigaldiePierre Mormède
Oct 7, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Frédéric LallemandPhilippe De Witte
Oct 5, 2018·Critical Reviews in Analytical Chemistry·Raimonda CeliesiuteArunas Ramanavicius
Nov 20, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·F Lallemand, P de Witte
Jun 29, 2005·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Hélène RouachFrançoise Beaugé
Mar 19, 2019·Neuropharmacology·Sophie LebourgeoisCatherine Vilpoux
May 9, 2018·Neuroscience and Biobehavioral Reviews·Jérôme JeanblancMickael Naassila

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