Ethanol metabolism in Drosophila melanogaster

M C Deltombe-LietaertA Elens


A quantitative study of the transformation of ethanol into acetaldehyde shows that, in Drosophila melanogaster, the mitochondrial ethanol oxidizing system is not very active but that the part played by catalase appears more important than expected. For a strain without alcoholdehydrogenase, ethanol is highly toxic. The presence of acetaldehyde in the culture medium is toxic for all the strains studied. But, since even a strain without any aldehydeoxidase lives normally, the metabolic production of acetaldehyde does not seem dangerous.


Jan 1, 1977·Alcoholism, Clinical and Experimental Research·R TeschkeC S Lieber
Jul 1, 1977·Archives of Biochemistry and Biophysics·P HavreB R Landau
Mar 1, 1976·Scientific American·C S Lieber
Aug 29, 1970·Nature·J B Gibson
Jun 14, 1968·Annals of the New York Academy of Sciences·E H GrellJ B Murphy


Aug 1, 1985·Biochemical Genetics·B W GeerS W McKechnie
Jan 15, 1985·Experientia·M C LietaertA Elens
Jan 1, 1982·European Journal of Biochemistry·M Best-Belpomme, M Ropp

Related Concepts

Alcohol Oxidoreductases
Aldehyde Oxidoreductases
Metabolic Biotransformation
Catalase T
Drosophila melanogaster

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