PMID: 1211063Dec 1, 1975

Ethanol metabolism in liver cirrhosis and chronic alcoholism

Acta Hepato-gastroenterologica
A Ginestal da CruzL Menezes

Abstract

Ethanol metabolism and its influence on serum lactate/pyruvate ratio was studied after intravenous infusion of ethanol in 17 patients: 4 controls, 5 alcoholics with cirrhosis, 4 non-alcoholic cirrhotics and 4 alcoholics without liver disease. All refrained from the use of alcohol and drugs 4 weeks prior to the experiment. After maximal ethanol blood levels were achieved at the end of the infusion, ethanol removal occurred at two different rates. This was probably due to the fact that different volumes of ethanol were distributed with time: a fast period (30 to 60 min) and a slow period (60 to 180 min). The rates of disappearence in the two periods were similar in all groups which suggests that liver cirrhosis, independent of clinical severity and/or chronic alcoholism with previous abstinence from alcohol, does not modify ethanol metabolic rates in the liver. The relation lactate/pyruvate doubled in all cases but it occurred within 30 minutes in the groups without liver disease and within 60 minutes in the cirrhotics. This could account for the decreased liability of cirrhotic patients to alcohol hypoglycemia.

Related Concepts

Ethanol
Alcohol Abuse
Intravenous Injections
Lactates
Fibrosis, Liver
Total Body Clearance Rate
Pyruvates

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.