Ethanol metabolites: their role in the assessment of alcohol intake

Alcoholism, Clinical and Experimental Research
F M WurstWolfgang Weinmann

Abstract

Alcohol-related disorders are common, expensive in their course, and often underdiagnosed. To facilitate early diagnosis and therapy of alcohol-related disorders and to prevent later complications, questionnaires and biomarkers are useful. Indirect state markers like gamma-glutamyl-transpeptidase, mean corpuscular volume, and carbohydrate deficient transferrin are influenced by age, gender, various substances, and nonalcohol-related illnesses, and do not cover the entire timeline for alcohol consumption. Ethanol (EtOH) metabolites, such as ethyl glucuronide, ethyl sulfate, phosphatidylethanol, and fatty acid ethyl esters have gained enormous interest in the last decades as they are detectable after EtOH intake. For each biomarker, pharmacological characteristics, detection methods in different body tissues, sensitivity/specificity values, cutoff values, time frames of detection, and general limitations are presented. Another focus of the review is the use of the markers in special clinical and forensic samples. Depending on the biological material used for analysis, ethanol metabolites can be applied in different settings such as assessment of alcohol intake, screening, prevention, diagnosis, and therapy of alcohol use disorders.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P S BoraL G Lange
Feb 13, 1987·Biochemical and Biophysical Research Communications·L Gustavsson, C Alling
Feb 7, 1983·FEBS Letters·C AllingE Anggård
Sep 1, 1996·Journal of Molecular and Cellular Cardiology·P S BoraM S Ruyle
Mar 13, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·F M WurstA Alt
May 27, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·F M WurstA Alt
Jul 27, 1999·The British Journal of Surgery·H Tonnesen, H Kehlet
Oct 8, 1999·American Journal of Clinical Pathology·M Laposata
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C SpiesK Conigrave
Mar 30, 2002·Alcoholism, Clinical and Experimental Research·Katherine M ConigraveUNKNOWN WHO/ISBRA Study Group
Jun 11, 2002·Journal of Analytical Toxicology·Helen DahlAnders Helander
Sep 14, 2002·The Journal of Laboratory and Clinical Medicine·Arthur Varga, Christer Alling
Mar 27, 2003·Alcoholism, Clinical and Experimental Research·Friedrich Martin WurstGregory E Skipper
Dec 24, 2003·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Friedrich Martin WurstFritz Pragst
Feb 10, 2004·Journal of the American Society for Mass Spectrometry·Wolfgang WeinmannFriedrich Martin Wurst
Feb 27, 2004·Addiction·Friedrich Martin WurstWolfgang Weinmann
Apr 24, 2004·Clinical Chemistry·Anders Helander, Olof Beck
Jul 30, 2004·The Biochemical Journal·Heiko Schneider, Hansruedi Glatt
Aug 4, 2004·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Gregory E SkipperFriedrich Martin Wurst
Aug 20, 2004·Alcoholism, Clinical and Experimental Research·Friedrich Martin WurstWolfgang Weinmann
Sep 7, 2004·Seminars in Liver Disease·Kamran Safdar, Eugene R Schiff
Nov 18, 2004·Alcoholism, Clinical and Experimental Research·Steina AradóttirChrister Alling
Sep 6, 2005·Forensic Science International : Synergy·Robert S Foti, Michael B Fisher
Jan 24, 2006·Lancet·Andrew K BurroughsUNKNOWN European Liver Transplant Association
Feb 1, 2006·Addiction·Friedrich Martin WurstWolfgang Weinmann
Feb 16, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Maria KellyPaul S Haber
Mar 11, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andrea DiMartiniPaulo Fontes
Apr 21, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Steina AradottirChrister Alling
Oct 19, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Onni Niemelä
Dec 2, 2006·Journal of Analytical Toxicology·Anthony CostantinoFrederic Rieders
Dec 2, 2006·Journal of Analytical Toxicology·Timothy P RohrigWayne Ross
Mar 6, 2007·Forensic Science International : Synergy·Brice M R AppenzellerRobert Wennig
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Yesim ErimAnders Helander
May 23, 2007·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Brice M R AppenzellerRobert Wennig
Jun 15, 2007·International Journal of Legal Medicine·Claudia C HalterWolfgang Weinmann

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Citations

Jan 19, 2016·Drug and Alcohol Dependence·Gerald W ValentineMehmet Sofuoglu
Oct 19, 2016·IUBMB Life·Christoph HeierRobert Zimmermann
Oct 21, 2016·Alcoholism, Clinical and Experimental Research·Judith A HahnMartin A Javors
Jan 6, 2017·Alcoholism, Clinical and Experimental Research·Robert Ross MacLeanMehmet Sofuoglu
Feb 2, 2017·Alcoholism, Clinical and Experimental Research·Wolfgang WeinmannFriedrich Martin Wurst
Mar 16, 2017·Alcoholism, Clinical and Experimental Research·Amy C JusticeHenry R Kranzler
Jul 8, 2017·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Erin M Goldberg, Michel Aliani
Nov 18, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Sander De BruyneJoris R Delanghe
Jul 31, 2018·Alcoholism, Clinical and Experimental Research·Majid AfsharErin M Lowery
Jun 9, 2017·Drug and Therapeutics Bulletin
Nov 24, 2018·Biomedical Chromatography : BMC·Yi He, Marta Concheiro-Guisan
Nov 12, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Irene PeriniMarkus Heilig
Oct 1, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Greer A RaggioJessica E Haberer
Sep 12, 2019·Alcoholism, Clinical and Experimental Research·Joanna StentonAnders Isaksson
Mar 4, 2020·Alcoholism, Clinical and Experimental Research·Theresa W KimRichard Saitz
Nov 8, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Oghenowede EyawoUNKNOWN VACS Project team
Jan 6, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Judith A HahnJeffrey H Samet
Mar 25, 2017·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Pablo BarrioAntoni Gual
Oct 2, 2016·Clinical Liver Disease·Joaquin CabezasRamon Bataller
Jun 15, 2019·Journal of Clinical Medicine·Pablo BarrioAntoni Gual
Jul 7, 2020·European Archives of Psychiatry and Clinical Neuroscience·Florian J RaabeGabriele Koller
Sep 26, 2020·Journal of Clinical Medicine·Pablo BarrioFriedrich M Wurst
Jun 9, 2020·Environmental Science and Pollution Research International·Nebile DagliogluHuseyin Dengiz
Jul 31, 2020·Addiction Science & Clinical Practice·E Jennifer EdelmanDavid A Fiellin
Aug 10, 2017·Alcoholism, Clinical and Experimental Research·Majid AfsharErin M Lowery
Oct 15, 2019·Alcoholism, Clinical and Experimental Research·Julian AdongJudith A Hahn
Sep 28, 2020·Alcoholism, Clinical and Experimental Research·Milan RöhrichtFriedrich Martin Wurst
Nov 11, 2020·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Isabella MercurioMauro Bacci
Nov 16, 2020·Alcoholism, Clinical and Experimental Research·Janique ArntsJef Verbeek
Jan 19, 2021·Alcoholism, Clinical and Experimental Research·Oghenowede EyawoE Jennifer Edelman
Mar 6, 2021·Alcoholism, Clinical and Experimental Research·Pablo BarrioJakob Manthey
Apr 15, 2018·Alcohol·Holly J HulsebusElizabeth J Kovacs
Oct 13, 2018·Alcohol·Erin M LoweryMajid Afshar
May 30, 2020·Addictive Behaviors Reports·Erica N GrodinLara A Ray
Jun 14, 2021·Alcoholism, Clinical and Experimental Research·Emily E HartwellHenry R Kranzler

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