PMID: 11910048Mar 23, 2002Paper

Ethanol modulates the growth of human breast cancer cells in vitro

Experimental Biology and Medicine
E B IzevbigieCarolyn B Howard

Abstract

The role of ethanol or its metabolites on breast neoplasm has not been characterized. We hypothesized that ethanol may alter the growth rate of human breast tumor epithelial cells by modulating putative growth-promoting signaling pathways such as p44/42 mitogen-activated protein kinases (MAPKs). The MCF-7 cell line, considered a suitable model, was used in these studies to investigate the effects of ethanol on [(3)H]thymidine incorporation, cell number, and p44/42 MAPK activities in the presence or absence of a MAPK or extracellular signal-regulated kinase ERK-1, and (MEK1) inhibitor (PD098059). Treatment of MCF-7 cells with a physiologically relevant concentration of ethanol (0.3% or 65 mM) increased p44/42 activities by an average of 400% (P < 0.02), and subsequent cell growth by 200% (P < 0.05) in a MEK1 inhibitor (PD098059)-sensitive fashion, thus suggesting that the Ras/MEK/MAPK signaling pathways are crucial for ethanol-induced MCF-7 cell growth.

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Citations

Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Moe Moe AyeJia Luo
Sep 9, 2006·Journal of Gastroenterology and Hepatology·Jia Luo
Jun 26, 2007·Journal of Applied Toxicology : JAT·G D CastroJ A Castro
Nov 30, 2010·Human & Experimental Toxicology·María Eugenia MacielGerardo Daniel Castro
Apr 11, 2014·Phytotherapy Research : PTR·Robbie Yat-Kan ChanChung-Hin Chui
Oct 11, 2014·World Journal of Clinical Oncology·Gerardo Daniel Castro, José A Castro
Dec 14, 2016·International Journal of Oncology·Robert GelfandNestor F Gonzalez-Cadavid
Feb 2, 2006·International Journal of Cancer. Journal International Du Cancer·Zunji KeJia Luo
Jan 22, 2005·Annals of the New York Academy of Sciences·Nicolas EtiqueIsabelle Grillier-Vuissoz
Mar 6, 2010·Alcoholism, Clinical and Experimental Research·Mei XuJia Luo
Feb 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mei XuJia Luo
Mar 19, 2004·Life Sciences·Annayya R Aroor, Shivendra D Shukla
Jun 9, 2006·Differentiation; Research in Biological Diversity·Ewan J D RobsonChristine J Watson

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