PMID: 8583149Nov 1, 1995Paper

Ethanol-related liver injury in the rat: a model of steatosis, inflammation and pericentral fibrosis

Journal of Hepatology
A KeeganR Batey

Abstract

While several animal models exist for the study of ethanol heptotoxicity, they are limited in their applicability. This paper describes a relatively simple rat model of alcohol-related liver injury. Ethanol was supplied in the drinking water in a concentration of 40% v/v for up to 29 weeks. Animals are concurrently supplied a chow diet which provides adequate protein and choline for normal growth. Total fat intake is low (7% of consumed calories). Histological changes of steatosis, inflammation, hepatocyte necrosis and pericentral sclerosis were evident in ethanol-treated rat livers. Littermate controls with and without pair-feeding had normal livers. Electron microscopy revealed abnormal mitochondria and a marked proliferation of smooth endoplasmic reticulum in livers of animals fed ethanol. Biochemical analysis revealed that levels of hepatic-free choline were similar in treated and pair-fed control rats. There was an expected increase in the activity of the microsomal enzyme cytochrome P450 2E1 in ethanol-fed rats. The model provides a convenient method for the production of alcoholic liver injury, and it may be useful for the study of the pathogenesis of ethanol-related liver disease.

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Citations

Oct 4, 2011·Indian Journal of Clinical Biochemistry : IJCB·P Vasanth RajN Udupa
Oct 2, 2012·Indian Journal of Clinical Biochemistry : IJCB·P Vasanth RajN Udupa
Jun 14, 2002·Alcohol·Robert G BateyBelinda Gould
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Jan 31, 2020·Oxidative Medicine and Cellular Longevity·Zhuqian WangDi Wang

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