Ethanol-related smooth endoplasmic reticulum dilation in purkinje dendrites of aging rats

Alcoholism, Clinical and Experimental Research
Cynthia A Dlugos

Abstract

Long-term ethanol consumption in aging rats results in degeneration and regression of the Purkinje neuron (PN) dendritic arbor. One marked ethanol-related change in Purkinje dendrite ultrastructure is dilation of the smooth endoplasmic reticulum (SER) within PN dendritic shafts. The purpose of this study was to determine a time course for ethanol-related dendritic regression in PN dendritic shafts and spines. One-hundred eighty aging, male Fischer 344 rats were used. Four durations of treatment (5, 10, 20, and 40 weeks) and 3 dietary treatment groups (60 rats/treatment group) were studied. Ethanol-fed rats received a liquid ethanol diet (35% of dietary calories from ethanol). Pair-fed rats received an isocaloric liquid control diet and chow-fed rats received rat chow and water ad libitum. After each duration of treatment, 45 rats (15/treatment) were euthanized and 2 posterior cerebellar lobules/rat were viewed with electron microscopy and photographed. Diameters of SER profiles within PN shafts and spines were measured with image analysis. Ethanol-related SER dilation in dendritic shafts occurred following 40 weeks of treatment. Ethanol-related SER dilation was not detected in PN dendritic spines. These results confirm that eth...Continue Reading

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Citations

Jul 26, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Linda L CassidyCynthia A Dlugos
Apr 18, 2018·Cellular and Molecular Neurobiology·Aikaterini BritzolakiPothitos M Pitychoutis

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