PMID: 15374666DOI: 10.1016/j.tins.2004.07.006Sep 18, 2004Paper
Ethanol targets: a BK channel cocktail in C. elegans
Trends in Neurosciences
C Michael Crowder
Abstract
A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1. slo-1 encodes the pore-forming subunit of a large-conductance Ca(2+)-activated K(+) channel previously shown to limit excitatory neurotransmitter release in C. elegans. Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release.
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