Ethanol targets: a BK channel cocktail in C. elegans

Trends in Neurosciences
C Michael Crowder

Abstract

A genetic screen for resistance to ethanol intoxication in Caenorhabditis elegans isolated mutants of the gene slo-1. slo-1 encodes the pore-forming subunit of a large-conductance Ca(2+)-activated K(+) channel previously shown to limit excitatory neurotransmitter release in C. elegans. Electrophysiological data recorded in vivo are consistent with a model in which ethanol potentiation of SLO-1 produces intoxication in C. elegans by reducing excitatory neurotransmitter release.

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Citations

Sep 29, 2009·Trends in Neurosciences·Steven N Treistman, Gilles E Martin
Sep 1, 2015·Behavioural Pharmacology·Seth A WescottX Z Shawn Xu
Feb 9, 2008·Biochimica Et Biophysica Acta·Jiuyong Xie
Jan 3, 2008·Biochemical and Biophysical Research Communications·Mingi HongJunho Lee
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Nov 23, 2012·Annals of the New York Academy of Sciences·Marcella Rietschel, Jens Treutlein
Feb 15, 2011·Alcoholism, Clinical and Experimental Research·Kenneth S KendlerPablo V Gejman
Sep 2, 2006·Biochimica Et Biophysica Acta·Juha-Matti AlakoskelaPaavo K J Kinnunen
Dec 3, 2014·Experimental Gerontology·Alexander Nikolich PatanananSteven Gerard Clarke
Nov 11, 2006·Annales pharmaceutiques françaises·J Savel, F Clostre
Jun 19, 2017·Pharmacology, Biochemistry, and Behavior·Avi ShahJiang-Hong Ye
Nov 17, 2006·Biotechnology Journal·Marta Artal-SanzNektarios Tavernarakis
Feb 28, 2007·The Pharmacogenomics Journal·P H MitchellV O'Connor
Jan 6, 2017·Alcoholism, Clinical and Experimental Research·Robert Ross MacLeanMehmet Sofuoglu
Jul 25, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James DillonLindy Holden-Dye

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