Ethanol tolerance caused by slowpoke induction in Drosophila

Alcoholism, Clinical and Experimental Research
R B CowmeadowNigel S Atkinson

Abstract

The large-conductance calcium-activated potassium channel encoded by the slowpoke gene has recently been implicated in the ethanol response. Caenorhabditis elegans carrying mutations in this gene have altered ethanol sensitivity and Drosophila mutant for this gene are unable to acquire rapid tolerance to ethanol or anesthetics. In Drosophila, induction of slowpoke expression has been linked to anesthetic resistance. We used Drosophila as a model system to examine the relationship between slowpoke expression and ethanol tolerance. Real-time PCR and a reporter transgene were used to measure slowpoke induction after ethanol sedation. An inducible slowpoke transgene was used to manipulate slowpoke levels in the absence of ethanol sedation. Ethanol sedation increased transcription from the slowpoke neural promoters but not from the slowpoke muscle/tracheal cell promoters. This neural-specific change was concomitant with the appearance of ethanol tolerance, leading us to suspect linkage between the two. Moreover, induction of slowpoke expression from a transgene produced a phenotype that mimics ethanol tolerance. In Drosophila, ethanol sedation induces slowpoke expression in the nervous system and results in ethanol tolerance. The in...Continue Reading

References

Jan 25, 1990·European Journal of Pharmacology·R A MorrisettH S Swartzwelder
Jun 1, 1997·The Journal of Membrane Biology·M JakabA Hermann
Feb 3, 1999·Annals of the New York Academy of Sciences·N S AtkinsonJ L Wilbur
Apr 21, 1999·Brain Research Bulletin·M D Madeira, M M Paula-Barbosa
Apr 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H A JärveläinenK O Lindros
Jul 16, 1999·Neurochemistry International·H J Walter, R O Messing
Mar 17, 2001·Nature Reviews. Neuroscience·E J Nestler
Aug 11, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·V K GribkoffS I Dworetzky
May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Victoria P Korovkina, Sarah K England
Jun 18, 2002·Molecular Pharmacology·Thomas K KnottSteven N Treistman
Feb 7, 2003·American Journal of Physiology. Cell Physiology·Alejandro M Dopico
Oct 24, 2003·Alcoholism, Clinical and Experimental Research·Pengchong LiuAlejandro M Dopico
Sep 24, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrzej Z PietrzykowskiSteven N Treistman
Oct 7, 2004·Neuropharmacology·Eric J Nestler
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Alfredo GhezziNigel S Atkinson
Sep 6, 2005·The Journal of Physiology·Jian Wei XuMalcolm M Slaughter
Nov 5, 2005·Alcoholism, Clinical and Experimental Research·R B CowmeadowN S Atkinson

❮ Previous
Next ❯

Citations

Feb 22, 2012·Human Genetics·Karla R KaunUlrike Heberlein
Feb 15, 2011·Behavior Genetics·Yazan M Al-HasanNigel S Atkinson
Feb 2, 2013·Behavior Genetics·Alfredo GhezziNigel S Atkinson
Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alfredo GhezziNigel S Atkinson
Apr 10, 2008·Genes, Brain, and Behavior·D KapfhamerS L McIntire
Feb 27, 2009·Genes, Brain, and Behavior·Y WangN S Atkinson
Oct 24, 2006·Genome Biology·Tatiana V MorozovaTrudy F C Mackay
Feb 22, 2012·Genome Biology·Tatiana V MorozovaRobert R H Anholt
Oct 19, 2007·PLoS Biology·Yan WangNigel S Atkinson
Dec 19, 2013·PLoS Genetics·Alfredo GhezziNigel S Atkinson
Nov 13, 2012·PloS One·Rajani MaiyaUlrike Heberlein
Oct 3, 2013·PloS One·Xiaolei LiNigel S Atkinson
Feb 18, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cristina Velázquez-MarreroSteven N Treistman
Jan 29, 2011·Genetics·Tatiana V MorozovaRobert R H Anholt
Jan 8, 2014·Molecular Genetics and Genomics : MGG·Tatiana V MorozovaRobert R H Anholt
Jan 31, 2009·Journal of Neurogenetics·Nigel S Atkinson
Mar 20, 2016·Alcohol·Harish R KrishnanNigel S Atkinson
Sep 29, 2009·Trends in Neurosciences·Steven N Treistman, Gilles E Martin
Jun 27, 2007·Alcohol·Richard W OlsenMartin Wallner
Aug 4, 2009·Alcoholism, Clinical and Experimental Research·Poonam BhandariMike Grotewiel
Apr 25, 2009·Alcoholism, Clinical and Experimental Research·Patrick J MulhollandL Judson Chandler
Sep 14, 2007·Alcoholism, Clinical and Experimental Research·Mark S BrodieAlejandro M Dopico
Jul 30, 2011·Alcoholism, Clinical and Experimental Research·Harish R KrishnanNigel S Atkinson
Jun 28, 2012·Addiction Biology·Alfredo GhezziNigel S Atkinson
Jul 16, 2015·Alcoholism, Clinical and Experimental Research·Mike Grotewiel, Jill C Bettinger
Jun 12, 2013·Communicative & Integrative Biology·Brooks G RobinsonNigel S Atkinson
Sep 25, 2014·Frontiers in Physiology·Jill C Bettinger, Andrew G Davies
Sep 2, 2016·Journal of Neurogenetics·Nigel S Atkinson
Dec 18, 2007·The Journal of Biological Chemistry·Chunbo YuanSteven N Treistman
Dec 13, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Diego CotellaFederico Sesti
May 3, 2013·Physiology·T HoshiR Olcese
Nov 16, 2016·Journal of Neurogenetics·Alfredo GhezziNigel S Atkinson
Apr 27, 2017·Frontiers in Molecular Neuroscience·Alfredo GhezziNigel S Atkinson
May 4, 2018·Frontiers in Physiology·Eve G Lowenstein, Norma A Velazquez-Ulloa
Sep 17, 2020·International Journal of Molecular Sciences·Daniel R LathenAdrian Rothenfluh
Jun 15, 2018·Journal of Experimental Neuroscience·Maria E Ramirez-RomanAlfredo Ghezzi
Jan 2, 2021·Frontiers in Behavioral Neuroscience·Maggie M ChvilicekAdrian Rothenfluh
Apr 20, 2021·Neuroscience Insights·Kristin M Scaplen, Emily Petruccelli
Jun 14, 2021·Alcoholism, Clinical and Experimental Research·Michelle BonillaMariano Loza-Coll

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Alcoholism, Clinical and Experimental Research
R B CowmeadowNigel S Atkinson
Proceedings of the National Academy of Sciences of the United States of America
A GhezziNigel S Atkinson
Proceedings of the National Academy of Sciences of the United States of America
A GhezziNigel S Atkinson
Alcoholism, Clinical and Experimental Research
Harish R KrishnanNigel S Atkinson
© 2022 Meta ULC. All rights reserved