Ethanolamine Utilization in Bacteria

MBio
Karan Gautam Kaval, Danielle A Garsin

Abstract

Ethanolamine (EA) is a valuable source of carbon and/or nitrogen for bacteria capable of its catabolism. Because it is derived from the membrane phospholipid phosphatidylethanolamine, it is particularly prevalent in the gastrointestinal tract, which is membrane rich due to turnover of the intestinal epithelium and the resident microbiota. Intriguingly, many gut pathogens carry the eut (ethanolamine utilization) genes. EA utilization has been studied for about 50 years, with most of the early work occurring in just a couple of species of Enterobacteriaceae Once the metabolic pathways and enzymes were characterized by biochemical approaches, genetic screens were used to map the various activities to the eut genes. With the rise of genomics, the diversity of bacteria containing the eut genes and surprising differences in eut gene content were recognized. Some species contain nearly 20 genes and encode many accessory proteins, while others contain only the core catabolic enzyme. Moreover, the eut genes are regulated by very different mechanisms, depending on the organism and the eut regulator encoded. In the last several years, exciting progress has been made in elucidating the complex regulatory mechanisms that govern eut gene exp...Continue Reading

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Citations

Mar 6, 2019·Journal of Bacteriology·Karan Gautam KavalDanielle A Garsin
May 30, 2019·Infection and Immunity·Katherine DadswellMichael B Prentice
Oct 15, 2019·Molecular Plant-microbe Interactions : MPMI·Susan MosquitoVittorio Venturi
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May 13, 2021·MBio·Joshua S MacCready, Anthony G Vecchiarelli
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Jun 10, 2021·Current Opinion in Microbiology·Michael B Prentice
Jun 29, 2021·Gut Microbes·Jennifer Y ChoAnsel Hsiao
Jan 25, 2020·ACS Synthetic Biology·Monica P McNerneyMark P Styczynski

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Methods Mentioned

BETA
electrophoretic mobility shift
X-ray
in vitro transcription

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