Ethanolic extract of Achillea wilhelmsii C. Koch improves pulmonary function and inflammation in LPS-induced acute lung injury mice.

Journal of Complementary & Integrative Medicine
Niloofar HonariMehran Hosseini

Abstract

Acute lung injury (ALI) is a life-threatening pulmonary dysfunction associated with severe inflammation. There are still no effective pharmacological therapies for the treatment of ALI. In this concern, several anti-inflammatory agents could be used as add-on therapy to inhibit inflammation. Achillea wilhelmsii (AW) C. Koch is a well-known medicinal plant in the Iranian ethnomedical practices with anti-inflammatory activity. This study was aimed to evaluate the efficacy of ethanolic extract of AW on lipopolysaccharide (LPS)-induced ALI in mice. The ALI model was established via the intra-tracheal (i.t.) administration of LPS (2 mg/kg) to male BALB/c mice. The ALI mice were divided into four groups (n=8 each) which intra-peritoneally (i.p.) treated with repeated doses of saline (model), dexamethasone (2 mg/kg), and AW (150-300 mg/kg) 1, 11 and 23 h post LPS administration. Twenty-four hours after the LPS challenge, bronchoalveolar lavage fluid (BALF) and lung tissue were evaluated for inflammatory cell influx, level of tumor necrosis factor-α (TNF-α) and histopathological changes. The AW (150-300 mg/kg) treated mice showed lower inflammatory cells infiltration in BALF and TNF-α level when compared to the model group. In addition...Continue Reading

References

May 4, 2000·The New England Journal of Medicine·L B Ware, M A Matthay
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·E AbrahamJ Arcaroli
Nov 4, 2010·Molecular Medicine·Jochen Grommes, Oliver Soehnlein
Dec 7, 2010·Expert Review of Respiratory Medicine·Hong ChenXiangdong Wang
Apr 20, 2011·Pulmonary Pharmacology & Therapeutics·Bin WangSu Min
Jan 1, 2013·Journal of Ethnopharmacology·Qiuhong WangKelvin Chan
Apr 2, 2015·Annals of the American Thoracic Society·Vito Fanelli, V Marco Ranieri
Oct 16, 2015·Critical Care Medicine·Saeed NasseriDongmei Wu
Jan 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Malarvizhi GurusamyDongmei Wu
Jul 5, 2016·Pulmonary Pharmacology & Therapeutics·Xia-Qing GaoZhi-Li Jiang
Oct 17, 2017·Journal of Traditional and Complementary Medicine·M MahmoudabadyM Soukhtanloo
May 1, 2018·American Journal of Respiratory Cell and Molecular Biology·Jorge Blázquez-PrietoGuillermo M Albaiceta
May 29, 2018·Journal of Ethnopharmacology·Nur AzizJae Youl Cho
Feb 27, 2019·European Journal of Pharmacology·Jinyan YeCaicun Zhou
Feb 28, 2019·Scientific Reports·Xiaona AnJianbo Wu
May 23, 2019·Respiratory Research·Saeideh SaadatMohammad Hossein Boskabady
Apr 9, 2020·Respiratory Research·Adrien CarlaUNKNOWN ESICM Translational Biology Group of the Acute Respiratory Failure section

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