Ethanolic extract of red seaweed Gracilaria fisheri and furanone eradicate Vibrio harveyi and Vibrio parahaemolyticus biofilms and ameliorate the bacterial infection in shrimp

Fish & Shellfish Immunology
Kulwadee KarnjanaKanokpan Wongprasert

Abstract

Bacteria respond to host immunity for their proliferation and survival by cell-cell communications such as biofilm formation, bioluminescence, and secreting virulence factors. In the biofilm form, bacteria are more resistant to various antimicrobial treatments and withstand the host's immune system. The approaches of deciphering biofilm formation for treating bacterial infections are therefore highly desirable. Recently, we have reported that the ethanolic extract of the red seaweed Gracilaria fisheri (G. fisheri) enhanced immune activities and inhibited growth of the luminescent bacteria Vibrio harveyi in shrimp. We undertook the present research study in order to evaluate and compare the effectiveness of the ethanolic extract from G. fisheri and furanone, a known biofilm inhibitor, in inhibiting the formation of clinically important Vibrio biofilms. The results showed that sub-lethal concentrations of both the ethanolic extracts (5, 10 and 100 μg ml-1) and furanone (5 μM) inhibited biofilm formation by V. harveyi and Vibrio parahaemolyticus and also light production (luminescence) in V. harveyi. It is known that V. harveyi mediated light production via autoinducer AI-2 pathway, we further determined whether the inhibitory eff...Continue Reading

Citations

Jul 28, 2019·Journal of Basic Microbiology·Suganya KannanMurugan Marudhamuthu
Nov 5, 2020·Biomimetics·Timothy Sullivan, Irene O'Callaghan
Feb 28, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Yan QiaoLijuan Feng
Jul 3, 2021·Journal of Environmental Sciences (China)·Tingting ZhaoJianrong Zhu
Aug 18, 2021·Fish & Shellfish Immunology·Alokesh Kumar GhoshWalter Luyten
Sep 3, 2021·International Journal of Biological Macromolecules·Sunisa KhongthongPipat Piewngam

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