Abstract
The influence of ethanolic extracts of Brassica campestris spp. rapa roots (EBR) on obesity was examined in imprinting control region (ICR) mice fed a high-fat diet (HFD) and in 3T3-L1 adipocytes. The ICR mice used were divided into regular diet, HFD, EBR (50 mg/kg/day EBR administered orally), and orlistat (10 mg/kg/day orlistat administered orally) groups. The molecular mechanism of the anti-obesity effect of EBR was investigated in 3T3-L1 adipocytes as well as in HFD-fed ICR mice. In the obese mouse model, both weight gain and epididymal fat accumulation were highly suppressed by the daily oral administration of 50 mg/kg EBR for 8 weeks, whereas the overall amount of food intake was not affected. EBR treatment induced the expression in white adipocytes of lipolysis-related genes, including beta(3)-adrenergic receptor (beta(3)-AR), hormone-sensitive lipase (HSL), adipose triglyceride lipase, and uncoupling protein 2. Furthermore, the activation of cyclic AMP-dependent protein kinase, HSL, and extracellular signal-regulated kinase was induced in EBR-treated 3T3-L1 cells. The lipolytic effect of EBR involved beta(3)-AR modulation, as inferred from the inhibition by the beta(3)-AR antagonist propranolol. These results suggest th...Continue Reading
References
Sep 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·J J EganC Londos
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·P StrålforsP Belfrage
May 15, 1994·Genes & Development·P TontonozB M Spiegelman
Mar 1, 1997·Nature Genetics·C FleuryC H Warden
Jun 4, 1999·Seminars in Cell & Developmental Biology·C LondosA R Kimmel
Jan 15, 2000·Biochimica Et Biophysica Acta·D L BrasaemleC Londos
Feb 15, 2000·The Journal of Biological Chemistry·G M CliffordS J Yeaman
Apr 15, 2000·Nature·P G Kopelman
Aug 15, 2000·Annual Review of Nutrition·C HolmJ A Contreras
Oct 3, 2001·The Journal of Biological Chemistry·A S GreenbergF B Kraemer
Dec 1, 2001·Reviews in Endocrine & Metabolic Disorders·G A Bray
Oct 19, 2002·Biochimica Et Biophysica Acta·Yi ZhangPhilip J Scarpace
Jan 23, 2003·Journal of Agricultural and Food Chemistry·Kelly WolfeRui Hai Liu
Feb 6, 2003·The American Journal of Chinese Medicine·Lucy DeyChun-Su Yuan
Jul 17, 2003·Acta Physiologica Scandinavica·C Erlanson-Albertsson
Dec 4, 2003·Biochemical Society Transactions·C Holm
Dec 4, 2003·Atherosclerosis·M John Chapman
Apr 23, 2004·Journal of Lipid Research·Weerapan KhovidhunkitCarl Grunfeld
Aug 12, 2004·Biological & Pharmaceutical Bulletin·Moonkyu KangHyunsu Bae
Sep 13, 2005·Journal of Cellular Biochemistry·Kyung-Joo ChoDo-Young Yoon
Sep 27, 2005·Cellular Signalling·González-Yanes Carmen, Sánchez-Margalet Víctor
Sep 29, 2005·American Journal of Physiology. Endocrinology and Metabolism·Matthew J WattMark A Febbraio
Dec 13, 2005·Analytical Biochemistry·Shen LuoRodney L Levine
Aug 15, 2006·Diabetologia·W T FestucciaY Deshaies
Oct 6, 2006·Obesity·Rexford S Ahima
Dec 1, 2006·Biochemical and Biophysical Research Communications·Hiroaki YajimaYoko Horino
Dec 5, 2006·Biological & Pharmaceutical Bulletin·Yang-Hee KimKyung-Tae Lee
Jan 9, 2007·Lancet·Raj S Padwal, Sumit R Majumdar
Jun 15, 2007·Biochimica Et Biophysica Acta·Katherine A Burns, John P Vanden Heuvel
Jul 17, 2007·Bioorganic & Medicinal Chemistry Letters·Jennifer A LafontainePaul Dasilva-Jardine
Nov 13, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Un Ju JungMyung-Sook Choi
Mar 4, 2008·Archives of Biochemistry and Biophysics·Jisook PangTaesun Park
Citations
Aug 31, 2010·Molecules and Cells·Young-Na HurBoe-Gwun Chun
Feb 26, 2013·Archives of Pharmacal Research·Qian WuNam-In Baek
Aug 24, 2011·Natural Product Research·Xiaoqin WangXuewu Zhang
Sep 1, 2011·Journal of Medicinal Food·Ji-Sun ShinKyung-Tae Lee
Apr 1, 2015·Journal of Medicinal Food·Hua LiTae-Sook Jeong
Aug 31, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ji Hee MoonKyung-Tae Lee
Jan 4, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Assunta RaiolaMaria Manuela Rigano
Mar 9, 2018·The Journal of Experimental Biology·Katharina BraunMartin Klingenspor
Dec 19, 2018·Journal of Food Science·Swastika PaulJi-Jun Chen
Nov 2, 2019·Food & Function·Meng XuGuodong Zheng
Oct 14, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suriyan PonnusamyRamesh Narayanan
Aug 4, 2020·Journal of Food Biochemistry·Kenia Mirozlava Favela-GonzálezNorma Margarita De la Fuente-Salcido
Dec 13, 2017·Journal of Evidence-based Complementary & Alternative Medicine·Azadeh HamediMahmoodreza Moein
Jan 1, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suriyan PonnusamyRamesh Narayanan
Oct 30, 2020·Phytotherapy Research : PTR·Eugenia Piragine, Vincenzo Calderone
Nov 22, 2020·International Journal of Molecular Sciences·Albino CarrizzoCarmine Vecchione
Jun 18, 2021·Food Science & Nutrition·Emad MolaeiGholamreza Karimi
Jul 17, 2012·Journal of Agricultural and Food Chemistry·Eu-Jin ChoKyung-Tae Lee