Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling.

American Journal of Physiology. Heart and Circulatory Physiology
Kristy L HouckMark Kester

Abstract

Diglycerides (DGs) are phospholipid-derived second messengers that regulate PKC-dependent signaling pathways. Distinct species of DGs are generated from inflammatory cytokines and growth factors. Growth factors increase diacyl- but not ether-linked DG species, whereas inflammatory cytokines predominately generate alkyl, acyl- and alkenyl, acyl-linked DG species in rat mesenchymal cells. These DG species have been shown to differentially regulate protein kinase C (PKC) isotypes. Ester-linked diacylglycerols activate PKC-epsilon and cellular proliferation in contrast to ether-linked DGs, which lead to growth arrest through the inactivation of PKC-epsilon. It is now hypothesized that ether-linked DGs inhibit mitogenesis through the inactivation of ERK and/or Akt signaling cascades. We demonstrate that cell-permeable ether-linked DGs reduce vascular smooth muscle cell growth by inhibiting platelet-derived growth factor-stimulated ERK in a PKC-epsilon-dependent manner. This inhibition is specific to the ERK pathway, since ether-linked DGs do not affect growth factor-induced activation of other family members of the MAPKs, including p38 MAPK and c-Jun NH(2)-terminal kinases. We also demonstrate that ether-linked DGs reduce prosurviva...Continue Reading

References

Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·B R GanongR M Bell
Jun 22, 1987·FEBS Letters·F HeymansM Castagna
Nov 30, 1984·Biochemical and Biophysical Research Communications·M C Cabot, S Jaken
Feb 1, 1994·Journal of Biochemistry·S ArakiH Hayashi
Oct 6, 1997·The Journal of Biological Chemistry·C B MeniceK G Morgan
Dec 5, 1998·Biochimica Et Biophysica Acta·M P Wymann, L Pirola
Apr 23, 1999·The Journal of Biological Chemistry·A G HarpurM D Waterfield
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·S SatoT Tsuruo
May 15, 2001·American Journal of Physiology. Cell Physiology·N A BourbonM Kester
Nov 28, 2001·The Journal of Biological Chemistry·Nicole A BourbonMark Kester
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 7, 2003·Methods in Molecular Medicine·Li-Ping Wang, Scott A Summers
Jul 4, 2003·Methods in Molecular Biology·Alexandra C Newton
Jan 20, 2004·Molecular and Cellular Biology·Lazaros C FoukasPeter R Shepherd
May 29, 2004·Biochimica Et Biophysica Acta·Pedro BritesRonald J A Wanders
Sep 21, 2004·The Journal of Biological Chemistry·M Dean ChamberlainDeborah H Anderson
Feb 1, 2005·Clinical Genetics·R J A Wanders, H R Waterham
Aug 19, 2005·Genes & Development·Koichi HamadaAkira Suzuki
Oct 10, 2006·Biochimica Et Biophysica Acta·Karin GorgasWilhelm W Just
Nov 23, 2006·Science's STKE : Signal Transduction Knowledge Environment·Domingo F BarberAna C Carrera
Feb 20, 2007·The Journal of Biological Chemistry·Todd E FoxMark Kester
Mar 16, 2007·American Journal of Physiology. Cell Physiology·Valerie G WalkerDaniel C Flynn

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Citations

Aug 27, 2013·Chemistry and Physics of Lipids·S MolinaG Reglero
Aug 18, 2010·Marine Drugs·Anne-Laure DeniauAlain B Legrand
Jan 10, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Tsuyoshi HirataMakoto Arita
Jan 13, 2021·Metabolites·Nikhil RangholiaStephen P Holly
Aug 31, 2020·Neurobiology of Disease·Fabian DorningerJohannes Berger

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