PMID: 2123719Dec 4, 1990Paper

Ether lysophospholipid-induced production of platelet-activating factor in human polymorphonuclear leukocytes

Biochimica Et Biophysica Acta
T SugiuraK Waku

Abstract

Human polymorphonuclear leukocytes (PMN) produced considerable amounts of platelet-activating factor (PAF) when exposed to various concentrations of lyso-PAF, especially in the absence of albumin. The amount of produced PAF in the presence of 5 microM lyso-PAF (without albumin) was 1.1 pmol/10 min per 2.5 X 10(6) cells, which was close to the level in the case of opsonized zymosan stimulation. We found that the activity of neither acetyltransferase nor acetylhydrolase was affected markedly by the treatment of cells with lyso-PAF, suggesting that the increased availability of lyso-PAF could be responsible for the induction of PAF synthesis. We also found that PAF synthesis was induced not only by lyso-PAF but also by ether-containing ethanolamine lysophospholipids, 1-alkenyl(alkyl)-sn-glycero-3-phosphoethanolamine (GPE). The addition of 1-alkenyl(alkyl)-GPE caused the degradation of pre-existing 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine (GPC) and an increased level of lyso-PAF, followed by the formation of PAF. By contrast, 1-acyl-GPC and 1-acyl-GPE failed to induce PAF production. These results suggest a possible key role of the availability of lyso-PAF in triggering the biosynthesis of PAF in human PMN.

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Citations

Mar 1, 1995·Journal of Lipid Mediators and Cell Signalling·G B Kudolo, M J Harper
Oct 31, 1998·Biochimica Et Biophysica Acta·T C Lee
May 1, 1997·Journal of Lipid Mediators and Cell Signalling·G B KudoloR A DeFronzo
Feb 1, 1995·Clinical and Experimental Pharmacology & Physiology·M E StrahanR R Taylor
Feb 3, 2004·Lipids in Health and Disease·Michiyo TomitaThomas J Santoro
May 18, 2000·Biochemical and Biophysical Research Communications·H ShindouT Shimizu
Feb 16, 2016·Progress in Lipid Research·Tomohiro KimuraRichard M Epand
Mar 9, 2018·Lipids in Health and Disease·Márcia Cristina Fernandes MessiasPatrícia de Oliveira Carvalho
Jul 7, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Marica BakovicVera Michel
Jan 5, 1996·Biochimica Et Biophysica Acta·F H ChiltonJ D Winkler
Jun 24, 1998·Biochimica Et Biophysica Acta·J R JacksonJ D Winkler
Aug 24, 1995·Biochimica Et Biophysica Acta·T SugiuraH Tsukatani

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