Ethical challenges in efficacy trials of vaginal microbicides for HIV prevention

American Journal of Public Health
I de ZoysaM E Bentley

Abstract

This paper discusses some of the ethical challenges raised by advanced clinical trials designed to assess the safety and efficacy of vaginal microbicides in protecting women from HIV infection. The ethical principles that guide clinical research involving human subjects require that all participants in such trials be provided available measures known to reduce the risk of HIV infection. However, this will reduce the ability of the study to assess the protective effect of the test microbicide. In addition, providing extensive services to trial participants may be construed as an undue inducement if the study is being conducted among vulnerable groups such as sex workers or women from disadvantaged communities. Suggestions are provided to resolve this dilemma in the planning and implementation of HIV prevention services for trial participants.

References

Nov 11, 1992·American Journal of Public Health·W CatesJ Trussell
Dec 16, 1992·JAMA : the Journal of the American Medical Association·S AllenS Hulley
Jan 1, 1991·Law, Medicine & Health Care : a Publication of the American Society of Law & Medicine·L Gostin
Apr 1, 1990·American Journal of Public Health·Z A Stein
Oct 20, 1988·The New England Journal of Medicine·M Barry
Oct 25, 1995·JAMA : the Journal of the American Medical Association·R J DiClemente, G M Wingood
Apr 1, 1995·Social Science & Medicine·L L Heise, C Elias
Oct 1, 1994·AIDS·K H Choi, T J Coates
Dec 1, 1994·American Journal of Public Health·J A KellyB Davantes
Dec 1, 1993·Culture, Medicine and Psychiatry·G R Gupta, E Weiss
Jan 26, 1994·JAMA : the Journal of the American Medical Association·P LurieJ Mandel
May 1, 1996·American Journal of Public Health·M O FinkelsteinH Robbins
Jan 1, 1996·AIDS·C F Cáceres, N Hearst
Jan 1, 1996·AIDS·W Rojanapithayakorn, R Hanenberg
Apr 12, 1997·Lancet·P M Rowe
Apr 1, 1997·International Journal of STD & AIDS·S K HiraJ C Thomas
Sep 19, 1997·The New England Journal of Medicine·M Angell
Oct 2, 1997·The New England Journal of Medicine·H Varmus, D Satcher

❮ Previous
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Citations

Aug 31, 2011·AIDS and Behavior·Elizabeth E TolleyRewa Kohli
Jul 3, 2007·SAHARA J : Journal of Social Aspects of HIV/AIDS Research Alliance·A G PistoriusA A Hoosen
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K H MayerZ Rosenberg
May 15, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Polly F HarrisonJana Bowcut
Mar 5, 2003·AIDS Patient Care and STDs·Sanjay GargLourens J D Zaneveld
Mar 11, 2003·Critical Care Medicine·Christine PaceMarion Danis
Jan 7, 2005·Journal of Medical Ethics·K Shapiro, S R Benatar
May 2, 2014·Journal of Empirical Research on Human Research Ethics : JERHRE·Joseph AliAdnan A Hyder
Jul 18, 2000·American Journal of Public Health·P Lurie, S M Wolfe
Jul 18, 2000·American Journal of Public Health·K M Wittkowski
Jul 18, 2000·American Journal of Public Health·I de ZoysaM E Bentley
Apr 29, 1998·American Journal of Public Health·M Susser
Apr 29, 1998·American Journal of Public Health·R Faden, N Kass
Feb 10, 2000·American Journal of Public Health·M Potts
Jan 1, 2010·AIDS Research and Treatment·Zachary A KwenaElizabeth A Bukusi
Jul 22, 2015·Developing World Bioethics·Bridget Haire, Christopher Jordens
Jun 28, 2011·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rabeea F Omar, Michel G Bergeron
Jul 2, 2014·BMC Medical Ethics·Rika MoorhouseGraham Lindegger
Nov 1, 2006·Current Opinion in HIV and AIDS·Zeda F RosenbergMark Mitchnick

❮ Previous
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