Ethical considerations in clinical research on herbal medicine for prevention of cardiovascular disease in the ageing

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
Nut Koonrungsesomboon, Juntra Karbwang

Abstract

Cardiovascular disease (CVD) in the ageing is a major public health problem worldwide. The nature of most CVD is subclinical with pathological processes that can span over years. Use of preventive measures could be an appropriate approach to prevailing over CVD in the ageing, and herbal medicine is one of the promising preventive approaches and is currently of interest among medical societies. In the evidence-based era, herbal medicine is, however, often underestimated and approached with skepticism, mainly due to the paucity of scientific evidence. Properly designed clinical trials on herbal medicine for prevention of CVD in a geriatric population are thus of importance and of clinical value. To review ethical issues and discuss considerations when such research is proposed. Four ethical issues, including the scientific validity of research, risk-benefit assessments, subject selection and vulnerability, and informed consent, are structured and extensively discussed in this article. Ethical core considerations of prevention research of CVD on herbal medicine involve particular attention on the scientific validity of research, risk-benefit assessments, subject selection and vulnerability, and informed consent. These issues and c...Continue Reading

References

Feb 5, 2000·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J B Calixto
May 20, 2000·JAMA : the Journal of the American Medical Association·E J EmanuelC Grady
Jun 8, 2000·The New England Journal of Medicine·J L NortierJ L Vanherweghem
Aug 10, 2001·JAMA : the Journal of the American Medical Association·P Y LeeE D Peterson
Sep 22, 2001·The New England Journal of Medicine·E J Emanuel, F G Miller
Oct 3, 2001·International Journal of Cancer. Journal International Du Cancer·R J Amdur, C J Biddle
Jan 1, 1994·European Journal of Health Law·Johan Legemaate
Dec 12, 2001·Journal of Advanced Nursing·R Harris, E Dyson
Feb 6, 2004·JAMA : the Journal of the American Medical Association·Franklin G MillerStephen E Straus
Apr 15, 2004·Journal of Medical Ethics·E ErnstJ Stone
Dec 24, 2005·Journal of Medical Ethics·S MasonJ Nixon
Jan 1, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Betty S BlackAdam Rosenblatt
Feb 2, 2008·Journal of the American Dietetic Association·Linda Van HornGeeta Sikand
Feb 19, 2008·Nature Reviews. Genetics·Jonathan Kimmelman
Aug 30, 2008·JAMA : the Journal of the American Medical Association·Robert B SaperStefanos N Kales
Sep 18, 2008·Bulletin of the World Health Organization·Jon C Tilburt, Ted J Kaptchuk
Oct 29, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Christopher Zaslawski
Feb 14, 2009·Disease-a-month : DM·William H FrishmanChristine Carosella
Jun 12, 2009·Drug Metabolism Reviews·Ulrich Klotz
Dec 1, 2009·Clinics in Geriatric Medicine·Ali Yazdanyar, Anne B Newman
Feb 16, 2010·Journal of the American College of Cardiology·Ara TachjianArshad Jahangir
Jul 17, 2010·Cardiovascular Therapeutics·Pieter A Cohen, E Ernst
Jan 5, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Caroline A SmithAlan Bensoussan
May 24, 2011·Biogerontology·Enn SeppetClaudio Franceschi
Feb 13, 2014·The Journal of Investigative Dermatology·Justin Besen, Stephanie D Gan
Aug 12, 2014·BioMed Research International·Tung-Ting ShamShun-Wan Chan
Dec 19, 2014·Circulation·Dariush MozaffarianUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 4, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Junhua ZhangMohamed Eddouks
May 8, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Foon Yin Fung, Yeh Ching Linn

❮ Previous
Next ❯

Citations

Aug 18, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Alexander N Orekhov
Sep 20, 2019·BMC Complementary and Alternative Medicine·Napatt KanjanahattakijChagriya Kitiyakara
Mar 3, 2017·Journal of Pharmaceutical Policy and Practice·Tsitsi G Monera-PendukaCharles F B Nhachi
Aug 11, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Nut KoonrungsesomboonNutthiya Hanprasertpong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.