Ethical observations on the choice of parenteral solvents. Choice of parenteral solvent

Drug Development and Industrial Pharmacy
Elise BracqMichel Guerbet

Abstract

The parenteral administration of insoluble drugs leads to the use of biologically active solvents inducing effects associated with ethical cause of concern including pain and pharmacological interactions. Selected vehicles currently used were ethically and scientifically reviewed. Our investigations allowed reinforcing the formulation decision tree with an ethical point of view. The last generation of cyclodextrin appears to be the safest solvent. Second choice could be lipidic emulsions, third choice being co-solvents, and finally non-ionic surfactants because of their hypersensitivity reactions. Screening tests including pH, osmolality measurements, cytotoxicity, and hemotoxicity, should allow to check the formulation tolerance before the animals' administration.

References

May 1, 1986·JPEN. Journal of Parenteral and Enteral Nutrition·O GouletC Ricour
Mar 1, 1984·JPEN. Journal of Parenteral and Enteral Nutrition·R S IzzoN Leissing
Jun 1, 1995·Alcoholism, Clinical and Experimental Research·M PagalaD Grob
May 1, 1994·The Annals of Pharmacotherapy·R T Dorr
Jul 8, 2003·Clinical Pharmacokinetics·Albert J ten TijeAlex Sparreboom
Jul 16, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sarah Gould, Robert C Scott
Dec 21, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K L Hennenfent, R Govindan

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