Ethics, industry, and outcomes

Seminars in Cardiothoracic and Vascular Anesthesia
Alan F Merry

Abstract

Evidence-based medicine depends on research that is reliable, well conducted, and free of influence from interest groups (which are not confined to industry). There are many ways to influence the outcome of clinical research, and the history of influence in research related to tobacco is illuminating in this regard. Health care depends on industry, and if properly managed, the relationship between industry and medical academia can be symbiotic. Achieving positive outcomes from such relationships depends on ensuring the presence of the elements needed for reasonable independence on the part of investigators, and on understanding the ways in which influence can be exerted over the production and publication of evidence. Regulation cannot substitute for integrity, particularly the integrity of the investigators. Pushing the limits of ethics in research threatens to undermine not only the reputation of those conducting the research but also the standing of science itself.

References

Dec 5, 1996·The New England Journal of Medicine·D BlumenthalK S Louis
Aug 1, 1997·Anesthesiology·D J Cullen
Jun 1, 2002·BMJ : British Medical Journal·Peter JüniPaul A Dieppe
Oct 16, 2004·BMJ : British Medical Journal·Paul A DieppePeter Jüni
Apr 22, 2005·Public Health Reports·Lisa A Bero
Sep 28, 2005·Academic Medicine : Journal of the Association of American Medical Colleges·Franklin G Miller, Howard Brody
Jan 27, 2006·The New England Journal of Medicine·Dennis T ManganoUNKNOWN Ischemia Research and Education Foundation
Mar 9, 2006·Annals of Internal Medicine·Harold C Sox, Drummond Rennie
Jul 11, 2006·The Journal of Clinical Investigation·Ushma S Neill
Nov 16, 2006·European Journal of Anaesthesiology·D RoystonP De Vooght
Nov 25, 2006·The New England Journal of Medicine·Jerry Avorn
Nov 25, 2006·The New England Journal of Medicine·William R Hiatt
Feb 8, 2007·JAMA : the Journal of the American Medical Association·Dennis T ManganoUNKNOWN Ischemia Research and Education Foundation
Feb 8, 2007·JAMA : the Journal of the American Medical Association·T Bruce Ferguson

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Citations

Jun 19, 2013·AJOB Primary Research·John LynchJoel Tsevat

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