PMID: 11931126Apr 5, 2002Paper

Ethics of clinical research in children

Seminars in Pediatric Neurology
Michael I Shevell

Abstract

The ethical conduct of clinical research in children is challenged by the inherent vulnerability of this population. Children are both incompetent decision makers and have a right to custody (ie, protection), yet they must also be participants in research that will advance the care of pediatric disorders or they risk becoming "therapeutic ophans." Consensus guidelines exist for the conduct of clinical research in children. Aspects of consent, risk-benefit ratios, fair subject selection, and respect for subjects have child-specific concerns. It is only by explicitly recognizing and addressing these child-specific concerns can the conduct of pediatric clinical research achieve and maintain a high level of ethical propriety.

References

Feb 1, 1997·Pediatric Clinics of North America·M Rowell, S Zlotkin
Apr 21, 1998·Seminars in Pediatric Neurology·M I Shevell
May 20, 2000·JAMA : the Journal of the American Medical Association·E J EmanuelC Grady

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Citations

Jan 22, 2005·Journal of Child Neurology·Amna Al-Futaisi, Michael Shevell
Nov 26, 2010·European Journal of Clinical Pharmacology·Annagrazia Altavilla
Jun 5, 2004·Nursing Ethics·Sølvi Helseth, Ashild Slettebø

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