Ethiodized oil-ethanol capillary embolization in rabbit kidneys: temporal histopathologic findings

Radiology
Andras KonyaKenneth C Wright

Abstract

To determine the temporal histopathologic findings associated with selective arterial injection of a 1:1 ethiodized oil-ethanol mixture (EEM) in normal rabbit kidney followed by administration of pure ethanol into the main renal artery. In five rabbits, the EEM was injected sequentially into each segmental renal artery of the right kidney until capillary stasis occurred. Pure ethanol was then injected into the main renal artery to achieve complete arterial stasis. Before sacrifice, the left kidney in each animal was acutely (ie, with a short follow-up period) embolized by using the same technique. The 10 kidneys of the five rabbits were evaluated microscopically at 1 (n = 3), 1(1/2) (n = 1), and 3 hours (n = 1) and 1 (n = 1), 3 (n = 1), 5 (n = 1), 7 (n = 1), and 14 days (n = 1) after embolization. Injection of the EEM (mean volume, 0.46 mL +/- 0.14 [SD]) followed by ethanol alone (mean volume, 0.25 mL +/- 0.09) led to complete stasis in all kidneys. There was no recanalization in the chronically (ie, with a longer follow-up period) embolized kidneys. Microscopically, uniform distribution of the EEM was evident in all slices at all time points. From 1 to 3 hours, sloughing of endothelium, formation of thrombi, and deposition of ...Continue Reading

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Citations

Nov 17, 2009·Cardiovascular and Interventional Radiology·Cagin SenturkA Yigit Goktay
Jan 21, 2011·Cardiovascular and Interventional Radiology·András KónyaKenneth C Wright
Sep 1, 2008·Seminars in Interventional Radiology·Colin P CantwellLeslie B Scorza
Jun 29, 2004·Radiology·Michael Darcy
Aug 18, 2005·Journal of Vascular and Interventional Radiology : JVIR·András Kónya
Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleni Liapi, Jean-Francois H Geschwind
Apr 11, 2007·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·András KónyaKenneth C Wright
Oct 14, 2011·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Sophie LerougeGilles Soulez

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