Ethnic and genetic factors of iron status in women of reproductive age

The American Journal of Clinical Nutrition
Victor R Gordeuk, Patsy M Brannon

Abstract

Background: African Americans are at increased risk of iron deficiency (ID) but also have higher serum ferritin (SF) concentrations than those of the general population. The Hemochromatosis and Iron Overload Screening (HEIRS) Study was a multicenter study of ethnically diverse participants that tested for the hemochromatosis (HFE) C282Y genotype and iron status.Objective: We sought to determine the prevalence and predictors of ID (SF concentration ≤15 μg/L) and elevated iron stores (SF concentration >300 μg/L) in HEIRS women of reproductive age (25-44 y).Design: The HEIRS Study was a cross-sectional study of iron status and HFE mutations in primary care patients at 5 centers in the United States and Canada. We analyzed data for women of reproductive age according to whether or not they were pregnant or breastfeeding at the time of the study.Results: ID was present in 12.5% of 20,080 nonpregnant and nonbreastfeeding women compared with 19.2% of 1962 pregnant or breastfeeding women (P < 0.001). Asian American ethnicity (OR ≤0.9; P ≤ 0.049) and HFE C282Y (OR ≤0.84; P ≤ 0.060) were independently associated with a decreased risk of ID in nonpregnant and nonbreastfeeding women and in pregnant or breastfeeding women. Hispanic ethnicit...Continue Reading

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Citations

Sep 17, 2019·Alcoholism, Clinical and Experimental Research·Nipun SainiSusan M Smith
Aug 1, 2018·Nutrients·Angela C FlynnUNKNOWN SCOPE and UBPEAT Consortiums
Oct 8, 2020·The Journal of Nutrition·Shanshan SheehyLynn Rosenberg
May 20, 2021·Advances in Nutrition·Wanhui KangKimberly O O'Brien

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