Ethnic differences in correlates of microalbuminuria in NIDDM. The role of the acute-phase response

Diabetes Care
N IslamJ C Pickup

Abstract

To investigate whether microalbuminuria is associated with markers of the acute-phase response in NIDDM and whether there are ethnic differences in this association among the three main racial groups in Malaysia. NIDDM patients of Chinese, Indian, and Malay origin attending a diabetic clinic in Kuala Lumpur, Malaysia, were matched for age, sex, diabetes duration, and glycemic control (n = 34 in each group). Urinary albumin-to-creatinine ratio was measured in an early morning urine sample. Biochemical measurements included markers of the acute-phase response: serum sialic acid, triglyceride, and (lowered) HDL cholesterol. The frequency of microalbuminuria did not differ among the Chinese, Indian, and Malay patients (44, 41, and 47%, respectively). In Chinese patients, those with microalbuminuria had evidence of an augmented acute-phase response, with higher serum sialic acid and triglyceride and lower HDL cholesterol levels; and urinary albumin-to-creatinine ratio was correlated with serum sialic acid and triglyceride. The acute-phase response markers were not different in Indians, with microalbuminuria being high in even the normoalbuminuric Indians; only the mean arterial blood pressure was correlated with urinary albumin-to-c...Continue Reading

Citations

Feb 5, 2000·Diabetes Research and Clinical Practice·I S IsmailB A Khalid
Mar 29, 2008·Metabolic Syndrome and Related Disorders·Joshua I Barzilaym, Eric S Freedland
Jul 23, 2013·Indian Journal of Endocrinology and Metabolism· GokulnathJasmeet Singh Sahni
Apr 21, 2006·Clinical Biochemistry·Karina P Gopaul, Martin A Crook
Nov 24, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xia DengGuoyue Yuan

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