Ethnic differences in genetic polymorphism associated with irritable bowel syndrome.

World Journal of Gastroenterology : WJG
Qi-Yun XiaoGui-Jun Fei

Abstract

Genetic polymorphism is associated with irritable bowel syndrome (IBS) in terms of susceptibility and clinical manifestations. Previous studies have shown that genetic polymorphism might play a key role in the onset and progression of IBS by modulating components of its pathogenesis such as the gut-brain axis, gastrointestinal motility, inflammatory activity, and immune status. Although underlying pathophysiological mechanisms have not been fully clarified, the potential ethnic differences that are present in worldwide genetic studies of IBS deserve attention. This review surveyed numerous studies focusing on IBS-associated single nucleotide polymorphisms, and investigated the ethnic disparities revealed by them. The results demonstrate the need for more attention on ethnic factors in IBS-related genetic studies. Taking ethnic backgrounds into accounts and placing emphasis on disparities potentially ascribed to ethnicity could help lay a solid and generalized foundation for transcultural, multi-ethnic, or secondary analyses in IBS, for example, a meta-analysis. Broader genetic studies considering ethnic factors are greatly needed to obtain a better understanding of the pathophysiological mechanisms of IBS and to improve the pre...Continue Reading

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·P J ConnP R Hartig
Mar 13, 1998·Gastroenterology·Q Aziz, D G Thompson
Oct 13, 1998·Alimentary Pharmacology & Therapeutics·M DelvauxJ Frexinos
Sep 20, 2000·Mayo Clinic Proceedings·G R LockeL J Melton
Oct 29, 2000·The American Journal of Gastroenterology·D Y Kim, M Camilleri
Jul 10, 2002·Gastroenterology·Jörg GlatzleHelen E Raybould
Oct 3, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Y OuG Farrugia
Feb 25, 2003·Lancet·Lon R Cardon, Lyle J Palmer
Aug 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Peter R StregeGianrico Farrugia
Nov 16, 2004·Nature Genetics·John P A IoannidisThomas A Trikalinos
May 11, 2005·Journal of Human Genetics·Mikako MoriKazuhiko Yamamoto
Nov 11, 2005·The American Journal of Gastroenterology·Patrick P J van der VeekAd A M Masclee
Oct 17, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J M ParkI-S Chung
Mar 27, 2007·Gastroenterology·Tobias LiebregtsGerald Holtmann
Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriAlan R Zinsmeister
Aug 6, 2008·European Journal of Gastroenterology & Hepatology·Charles D GersonWei-An Wang
Dec 6, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuri A SaitoGianrico Farrugia
Oct 17, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Arbab SikanderKartar Singh
Oct 22, 2009·Neuromodulation : Journal of the International Neuromodulation Society·Alexandru Gaman, Braden Kuo
Oct 22, 2009·Journal of Clinical Immunology·Elham BarkhordariAli Akbar Amirzargar
Mar 27, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H-J LeeC J Jin
Jun 11, 2010·Journal of Neurogastroenterology and Motility·Seon-Young ParkSung-Kyu Choi
Feb 18, 2011·Journal of Clinical Gastroenterology·Theofano MarkoutsakiDimitrios G Karamanolis
Jun 4, 2011·Gut·Marco ZucchelliMauro D'Amato
Jan 25, 2012·The American Journal of Gastroenterology·Max SchmulsonGabriela Gutiérrez-Reyes
Jan 28, 2012·Therapeutic Advances in Gastroenterology·Arthur Beyder, Gianrico Farrugia
Jun 29, 2012·Molecular Biology Reports·Mirza Romero-ValdovinosAngélica Olivo-Díaz
Jan 12, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Michael CamilleriAlan R Zinsmeister

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Nov 21, 2020·International Journal of Molecular Sciences·Yoshiyuki Mishima, Shunji Ishihara

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