Ethnic differences in levels of bone and cartilage biomarkers and hormonal responsiveness in nine groups of postmenopausal Asian women: the Pan-Asia Menopause (PAM) study

Climacteric : the Journal of the International Menopause Society
C F HolinkaM K Ausmanas

Abstract

Significant differences in baseline lipid and reproductive hormone profiles and in responsiveness of lipids to hormone therapy (HT) have previously been found among nine ethnic groups of Asian postmenopausal women participating in the Pan-Asia Menopause (PAM) study. Based on these findings, the primary objective of this study was to test the hypothesis that biomarkers of bone turnover and cartilage degradation and their responsiveness to HT differ among the ethnic groups. The PAM study was a prospective, randomized, double-blind clinical trial evaluating 1028 postmenopausal women at 22 clinical centers in 11 Asian countries/territories. Subjects were randomized to one of three continuous combined conjugated estrogens (CE)/medroxyprogesterone acetate (MPA) doses: CE/MPA (in mg/day) = 0.625/2.5; 0.45/1.5; and 0.3/1.5. Following baseline evaluations, subjects received therapy for six continuous 28-day cycles (6 months). Biomarkers for bone resorption (alphaalphaCTX and betabetaCTX, representing newly synthesized and old bone, respectively), bone formation (osteocalcin) and cartilage degradation (CTX-II) were analyzed centrally by state-of-the-art methods. The baseline concentrations of the four biomarkers were significantly associ...Continue Reading

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Sep 14, 2007·Climacteric : the Journal of the International Menopause Society·M K AusmanasC F Holinka

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Citations

May 16, 2013·Climacteric : the Journal of the International Menopause Society·T J de VilliersUNKNOWN International Menopause Society
Aug 13, 2013·Climacteric : the Journal of the International Menopause Society·R J Baber
Jun 17, 2008·Climacteric : the Journal of the International Menopause Society·H J T Coelingh BenninkE Diczfalusy
May 14, 2011·Climacteric : the Journal of the International Menopause Society·D W SturdeeJ C Stevenson
Jun 17, 2008·Climacteric : the Journal of the International Menopause Society·H J T Coelingh BenninkC Christiansen
Aug 11, 2017·Menopause : the Journal of the North American Menopause Society·Yves Muscat Baron

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