Ethnic differences in TGFβ-signaling pathway may contribute to prostate cancer health disparity

Carcinogenesis
Bethtrice ElliottShafiq A Khan

Abstract

Epidemiological studies show that the incidence and mortality rates of prostate cancer (PCa) are significantly higher in African-American (AA) men when compared with Caucasian (CA) men in the United States. Transforming growth factor β (TGFβ) signaling pathway is linked to health disparities in AAs. Recent studies suggest a role of TGFβ3 in cancer metastases and its effect on the migratory and invasive behavior; however, its role in PCa in AA men has not been studied. We determined the circulating levels of TGFβ3 in AA and CA men diagnosed with PCa using ELISA. We analyzed serum samples from both AA and CA men diagnosed with and without PCa. We show that AA PCa patients had higher levels of TGFβ3 protein compared with AA controls and CA patients. In fact, TGFβ3 protein levels in serum were higher in AA men without PCa compared with the CA population, which may correlate with more aggressive disease seen in AA men. Studies on AA-derived PCa cell lines revealed that TGFβ3 protein levels were also higher in these cells compared with CA-derived PCa cell lines. Our studies also reveal that TGFβ does not inhibit cell proliferation in AA-derived PCa cell lines, but it does induce migration and invasion through activation of PI3K pathw...Continue Reading

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Citations

Aug 6, 2018·Journal of Cellular Physiology·Silvia CaggiaShafiq A Khan
Nov 6, 2018·Biological Chemistry·Elham Abedini Bakhshmand, Bahram Mohammad Soltani
Mar 7, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hersh K BhargavaAnant Madabhushi
Nov 18, 2020·International Journal of Environmental Research and Public Health·Humberto ParadaJeannette T Bensen
May 18, 2021·Frontiers in Cell and Developmental Biology·Sanjay MishraRamesh K Ganju
Jul 18, 2021·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Sudha SivaramSatish Gopal

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