Ethnic differences in the prevalence of diabetes in underweight and normal weight individuals: The CARRS and NHANES studies

Diabetes Research and Clinical Practice
Unjali P GujralK M Venkat Narayan

Abstract

Type 2 diabetes in lean individuals has recently come to attention. We assessed type 2 diabetes prevalence and the associated risk factors in underweight and normal weight individuals in two ethnic populations. We conducted cross-sectional analyses, using representative samples of 4930 Asian Indians from the CARRS-Chennai Study and 2868 Whites from the NHANES Survey. Diabetes was defined as use of glucose lowering medication, fasting glucose ≥126 mg/dl, or 2 h glucose ≥200 mg/dl. Body mass index (BMI) was classified using WHO standard criteria. Prevalence of type 2 diabetes by BMI varied by ethnicity and sex. In men, type 2 diabetes prevalence was 5.4% and 23.5% in underweight and normal weight Asian Indians and 0.0% and 6.1% in underweight and normal weight Whites. In women, the prevalence was 5.6% and 13.6% in underweight and normal weight Asian Indians and 2.3% and 2.8% in underweight and normal weight Whites. Adjustment for waist circumference, insulin resistance, and insulin secretion did not explain the increased prevalence in Asian Indians. These findings suggest significant ethnic differences in type 2 diabetes prevalence without overweight or obesity. Future studies should examine the pathophysiology of type 2 diabetes...Continue Reading

Citations

May 31, 2019·Diabetes/metabolism Research and Reviews·Lisa R StaimezK M Venkat Narayan
Dec 5, 2019·European Heart Journal·Carolyn S P LamAdriaan A Voors
Jan 31, 2019·World Journal of Diabetes·Patil SuvarnaJoglekar Charudatta
Apr 2, 2020·Current Diabetes Reports·Hanna Bjørk KlitgaardFaidon Magkos
Nov 22, 2019·Diabetes Care·Unjali P Gujral, K M Venkat Narayan
Mar 28, 2021·BMJ Open Diabetes Research & Care·K M Venkat NarayanViswanathan Mohan
May 21, 2021·Journal of Atherosclerosis and Thrombosis·Nobuo SasakiYukihito Higashi
Nov 14, 2020·BMC Endocrine Disorders·Anuradha RajamanickamSubash Babu

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