Ethnic differences in the relationship between adiponectin and insulin sensitivity in South Asian and Caucasian women

Diabetes Care
Marlene MartinPeter D Reaven

Abstract

To assess whether lower adiponectin concentrations in South Asian Indians may be responsible for their greater degree of insulin resistance. Insulin-mediated glucose uptake and plasma total and high molecular weight (HMW) adiponectin concentrations were quantified in 52 women of South Asian (SA) and Caucasian (CAU) ancestry and compared. Mean +/- SD total (2,965 +/- 1,278 vs. 4,235 +/- 160 ng/ml) and HMW (1,001 +/- 352 vs. 1,591 +/- 854 ng/ml) adiponectin were lower in SAs than CAUs (P < 0.005). Insulin-resistant CAUs (CAU-IR) had lower total (2,665 +/- 1,040 vs. 5,133 +/- 1,086 ng/ml) and HMW (987 +/- 479 vs. 1,935 +/- 838 ng/ml) adiponectin than insulin-sensitive CAUs (CAU-IS) (P < 0.01), but there were no significant differences between insulin-resistant (SA-IR) and insulin-sensitive (SA-IS) SAs. HMW adiponectin did not differ between SA-IR and CAU-IR, but SA-IS had significantly lower adiponectin concentrations than CAU-IS. Insulin resistance status is not associated with significantly lower levels of adiponectin in these SA women, in contrast to the CAU women.

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Citations

Sep 29, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H GaoR M van Dam
Feb 19, 2011·Mediators of Inflammation·Shannon M ConroyGertraud Maskarinec
May 15, 2013·Journal of Diabetes Research·D R WebbM J Davies
Aug 14, 2013·European Journal of Endocrinology·Leontine E H BakkerIngrid M Jazet
Apr 24, 2015·International Journal of Pediatric Endocrinology·Koji TakemotoMarwah Abdalla
Dec 3, 2015·Current Obesity Reports·Kalypso Karastergiou
Jan 22, 2009·Metabolism: Clinical and Experimental·Sangyeoup Lee, Michael D Jensen
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Feb 10, 2010·Journal of Endocrinological Investigation·J ZaletelJ Prezelj
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