Ethnic variations in the epidemiology of bullous pemphigoid in Israel

International Journal of Dermatology
Khalaf Kridin, Reuven Bergman

Abstract

No ethnic or geographic predisposition to bullous pemphigoid (BP) was reported so far. To evaluate trends in the incidence of BP in northern Israel, shedding light on differences between two distinct ethnic populations who inhabit the same region, namely Jews and Arabs. Bullous pemphigoid incidence was retrospectively estimated from January 2000-December 2015 in two Israeli regions with a total population of 1.56 million inhabitants. A total of 287 new-onset BP patients (mean age: 77.6 ± 12.1) were identified. The incidence rate was 11.4 per million inhabitants per year (95% CI, 10.2-12.9). The crude incidence rate in Jews was 4.8-fold higher than that in Arabs (16.4 vs. 3.4 cases per million per year, respectively [P < 0.0001]). After adjusting for age, the discrepancy between the two populations diminished (11.7 vs. 8.9 cases per million per year, respectively) but remained statistically significant (P = 0.032). The incidence increased consistently from 7.6 cases per million per year in the calendar period 2000-2005 to 12.6 and 14.3 cases in 2006-2010 and 2011-2015, respectively (P < 0.0001). Bullous pemphigoid patients of Arab ancestry presented with the disease significantly earlier than Jews (69.5 ± 15.3 vs. 78.7 ± 11.1 ye...Continue Reading

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Citations

Nov 2, 2018·Archives of Dermatological Research·Mati RozenblatMichael Ziv
Aug 20, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·Y Ben MordehaiS Baum
Nov 7, 2019·Frontiers in Immunology·Khalaf Kridin, A Razzaque Ahmed
Sep 5, 2018·Frontiers in Medicine·Khalaf Kridin, Ralf J Ludwig
Oct 14, 2020·Experimental Dermatology·Camilla MargaroliRon J Feldman
Jun 22, 2021·Annual Review of Biochemistry·Xuelang MuTamir Gonen
Jun 17, 2020·The Journal of Dermatological Treatment·Pedro Miguel GarridoPaulo Filipe
Jul 14, 2021·PloS One·Omayma SiddigAhmed M Suleiman
Oct 14, 2021·The Australasian Journal of Dermatology·Murat DurduSoner Uzun
Mar 1, 2021·Dermatology : International Journal for Clinical and Investigative Dermatology·Khalaf KridinArnon D Cohen
Sep 5, 2021·The British Journal of Dermatology·M S M PerssonS Gran
Jan 27, 2022·Journal of Cosmetic Dermatology·Lingling LuAimin Liu

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