Abstract
Over the last century the incidence of cutaneous melanoma has increased worldwide, a trend that has also been observed in Brazil. The identified risk factors for melanoma include the pattern of sun exposure, family history, and certain phenotypic features. In addition, the incidence of melanoma might be influenced by ethnicity. Like many countries, Brazil has high immigration rates and consequently a heterogeneous population. However, Brazil is unique among such countries in that the ethnic heterogeneity of its population is primarily attributable to admixture. This study aimed to evaluate the contribution of European ethnicity to the risk of cutaneous melanoma in Brazil. We carried out a hospital-based case-control study in the metropolitan area of Sao Paulo, Brazil. We evaluated 424 hospitalized patients (202 melanoma patients and 222 control patients) regarding phenotypic features, sun exposure, and number of grandparents born in Europe. Through multivariate logistic regression analysis, we found the following variables to be independently associated with melanoma: grandparents born in Europe-Spain (OR = 3.01, 95% CI: 1.03-8.77), Italy (OR = 3.47, 95% CI: 1.41-8.57), a Germanic/Slavic country (OR = 3.06, 95% CI: 1.05-8.93), ...Continue Reading
References
Jun 1, 1988·Archives of Dermatology·T B Fitzpatrick
Jul 1, 1984·Mutation Research·V W Liu-LeeB Broughton
Nov 20, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R A SturmM Ramsay
Apr 29, 1999·The New England Journal of Medicine·B A GilchrestM Yaar
Sep 4, 1999·The New England Journal of Medicine·T Mack
Mar 10, 2001·Carcinogenesis·D TomescuD W Melton
May 1, 2001·International Journal of Dermatology·D Loria, E Matos
Aug 15, 2002·Nucleic Acids Research·Sikandar G KhanKenneth H Kraemer
Jul 29, 2003·Melanoma Research·M C Swan, D A Hudson
Mar 11, 2004·The Journal of Investigative Dermatology·Hao Ou-YangNikiforos Kollias
Jul 21, 2004·Archives of Dermatology·Shasa HuRobert S Kirsner
Aug 18, 2004·BMC Cancer·Ronald T ActonJames C Barton
Sep 24, 2004·Physiological Reviews·Andrzej SlominskiJacobo Wortsman
Apr 20, 2005·Archives of Dermatology·Melody J Eide, Martin A Weinstock
Apr 29, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·T NijstenM Garmyn
Aug 30, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sara GandiniCarmelo Francesco Melchi
Sep 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E de VriesJ W W Coebergh
Nov 1, 2005·Carcinogenesis·Robert C MillikanMarianne Berwick
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Chunying LiQingyi Wei
Apr 17, 2007·American Journal of Human Genetics·Marc BauchetMark D Shriver
Feb 12, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·L BakosD Benzano
Mar 20, 2009·Human Molecular Genetics·Richard A Sturm
Apr 11, 2009·International Journal of Epidemiology·Yu-mei ChangJulia A Newton-Bishop
Jul 28, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R M MacKieA M M Eggermont
Nov 6, 2009·American Journal of Epidemiology·Anne E CustGraham J Mann
Dec 2, 2009·Photochemistry and Photobiology·Marcelo de Paula Corrêa, Juan Carlos Ceballos
Jun 22, 2010·Journal of Toxicology and Environmental Health. Part a·Gelcio L Q MendesSergio Koifman
Mar 2, 2011·PloS One·Sérgio D J PenaGuilherme Suarez-Kurtz
Jul 8, 2011·Journal of Dermatological Science·Fernanda T GonçalvesJosé Eluf-Neto
Citations
Jan 28, 2014·Journal of Dermatological Science·Cristiane OliveiraCarmen Silvia Passos Lima
Apr 30, 2013·Melanoma Research·Guilherme FranciscoRoger Chammas
Apr 20, 2016·Journal of Skin Cancer·Sonia KamathMyles G Cockburn
May 28, 2015·BMC Cancer·Mónica CappettaBernardo Bertoni
Sep 12, 2018·Melanoma Research·Andréia C de MeloLuiz C S Thuler
Nov 18, 2018·International Journal of Cancer. Journal International Du Cancer·Corina S RueeggMarit B Veierød
Jun 11, 2014·American Journal of Therapeutics·Alberto WainsteinPiotr Rutkowski
Feb 23, 2019·Human Genomics·Julyann Pérez-MayoralMarcia Cruz-Correa