Ethnicity determines association of p53Arg72Pro alleles with cervical cancer in China

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Xing-zheng ZhengJin-Fang Jiang

Abstract

Minority Uigur women residing in Xinjiang, in the northwest of China, have a high incidence of cervical carcinoma (CC; 527/100 000) and are often diagnosed young. We favor the hypothesis that Uigur women may carry different genetic factor(s) making them more susceptible to CC than majority Han (Chinese) women living in the same region. Using PCR-restriction fragment length polymorphism, we investigated associations of a p53Arg72Pro polymorphism with CC in Uigur women compared with those in Han women. The study included 152 Uigur patients with CC and 110 controls, and 120 Han patients with CC and 122 controls. In Uigur women, CC was associated with p5372Arg/Arg homozygosity (chi=7.196, P<0.05) and with human papillomavirus-16 (chi=7.177, P<0.05). In Han women, however, CC was associated with p5372Pro/Pro homozygosity (chi=8.231, P<0.05). These observations suggest that individuals with different genetic backgrounds carry different susceptibilities to CC, at least in the Uigur and Han ethnic women studied in China.

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Citations

Jul 28, 2010·Medical Oncology·Patricia Piña-SánchezMauricio Salcedo
Mar 3, 2010·Cancer Genetics and Cytogenetics·Pei JiangJianxin Tang
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Xin ZhouShu-Lan Zhang
Aug 20, 2016·Infectious Agents and Cancer·Hongchang HeRenfu Shao
Nov 2, 2013·Journal of Clinical Nursing·Domingo Palacios-CeñaCésar Fernández-de-las-Peñas
Oct 16, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven HabbousGeoffrey Liu

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