Ethnicity-specific association of BMI levels at diagnosis of type 2 diabetes with cardiovascular disease and all-cause mortality risk

Acta Diabetologica
Ebenezer S Adjah OwusuS K Paul

Abstract

To evaluate the risk of CVD and all-cause mortality at different BMI levels in conjunction with weight change prior to diagnosis of T2DM in a multi-ethnic population. Longitudinal study of 51,455 patients with T2DM and without a history of comorbid diseases at diagnosis. Weight changes prior to diagnosis of T2DM were evaluated, and the risk of CVD and all-cause mortality at different BMI levels among three ethnic groups estimated using treatment effects model. White Europeans (WE), African-Caribbeans (AC), and South Asians (SA) were mean 52, 49, and 47 years with a mean BMI of 33.0, 32.0, and 30.0 kg/m2 at diagnosis, respectively. Among WE, normal weight patients developed CVD significantly earlier by 0.5 years (95% CI 0.1, 0.9 years; p = 0.018) compared to obese patients. Furthermore, those with normal body weight at diagnosis were significantly more likely to die earlier by 0.6 years (95% CI 0.03, 1.2 years; p = 0.037) among WE and by 2.5 years (95% CI 0.3, 4.6 years; p = 0.023) among SA compared to their respective obese patients. However, BMI at diagnosis was not associated with increased risk of CVD and death among AC. This study suggests a paradoxical association of BMI with cardiovascular and mortality risks in different...Continue Reading

References

Sep 29, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A MisraV P Gupta
May 10, 2006·Diabetic Medicine : a Journal of the British Diabetic Association·H E MulnierR A Lawrenson
Jun 22, 2011·Clinical Pharmacology and Therapeutics·C J LavieH O Ventura
Sep 1, 2011·Mayo Clinic Proceedings·Carl J LavieRichard V Milani
Aug 9, 2012·JAMA : the Journal of the American Medical Association·Mercedes R CarnethonAlan R Dyer
Nov 10, 2012·Diabetes Care·Jennifer LogueUNKNOWN Scottish Diabetes Research Network Epidemiology Group
Apr 4, 2013·Epidemiology·Hailey R Banack, Jay S Kaufman
Aug 2, 2013·Diabetes Care·Vojtech Hainer, Irena Aldhoon-Hainerová
Feb 18, 2014·Journal of the American College of Cardiology·Carl J LavieSteven N Blair
Dec 4, 2014·The Lancet. Diabetes & Endocrinology·Anoop Dinesh ShahHarry Hemingway
Dec 30, 2014·Diabetes Care·William C HsuWilfred Fujimoto
Apr 14, 2015·Annals of Epidemiology·Hailey R Banack, Jay S Kaufman

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