Ethnicity-specific impact of HLA I/II genotypes on the risk of inhibitor development: data from Korean patients with severe hemophilia A

Annals of Hematology
Hyun-Young KimHee-Jin Kim

Abstract

Inhibitor development is the most serious complication in patients with hemophilia. We investigated association of HLA genotypes with inhibitor development in Korean patients with severe hemophilia A (HA). HLA genotyping was done in 100 patients with severe HA including 27 patients with inhibitors. The allele frequencies between inhibitor-positive and inhibitor-negative patients were compared. HLA class I alleles were not associated with the inhibitor status. In HLA class II, DRB1*15 [n = 100, odds ratio (OR) 0.217, P = 0.028] and DPB1*05:01 [OR 0.461, P = 0.026] were negatively associated with inhibitor development. In a subgroup of patients with intron 22 inversion, C*07:02 was positively associated with inhibitor development [n = 30, OR 5.500, P = 0.043]. In the subgroup of patients without intron 22 inversion, the negative association between DPB1*05:01 and inhibitor development was reinforced [n = 70, OR 0.327, P = 0.010], and positive association of DRB1*13:02 and DPB1*04:01 with inhibitor development was identified [OR 3.059, P = 0.037 for both]. Previously reported risk alleles were not consistently associated with inhibitor risk in our series. This study demonstrated the profile of HLA alleles associated with inhibitor...Continue Reading

References

Jul 5, 2002·Seminars in Thrombosis and Hemostasis·Jens KlingeEvgueni L Saenko
Feb 9, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·E A ChalmersUNKNOWN Paediatric Working Party of UKHCDO
May 13, 2008·Blood·Sébastien Lacroix-DesmazesSuryasarathi Dasgupta
Jul 1, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·M V RagniUNKNOWN Hemophilia Inhibitor Study
Feb 20, 2010·Seminars in Thrombosis and Hemostasis·Samantha C Gouw, H Marÿke van den Berg
Jul 6, 2011·Haemophilia : the Official Journal of the World Federation of Hemophilia·M F De BarrosJ E L Visentainer
Jun 30, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·H-J KimH-J Kim
Apr 24, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·H PergantouH Platokouki
Sep 17, 2013·Nature Medicine·Gouri Shankar PandeyUNKNOWN PATH (Personalized Alternative Therapies for Hemophilia) Study Investigators
Jan 16, 2016·Blood Research·Ji Eun RyuYong-Mook Choi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.